HSP70 sequestration by free α-globin promotes ineffective erythropoiesis in β-thalassaemia

被引：0

作者：

Jean-Benoît Arlet

Jean-Antoine Ribeil

Flavia Guillem

Olivier Negre

Adonis Hazoume

Guillaume Marcion

Yves Beuzard

Michaël Dussiot

Ivan Cruz Moura

Samuel Demarest

Isaure Chauvot de Beauchêne

Zakia Belaid-Choucair

Margaux Sevin

Thiago Trovati Maciel

Christian Auclair

Philippe Leboulch

Stany Chretien

Luba Tchertanov

Véronique Baudin-Creuza

Renaud Seigneuric

Michaela Fontenay

Carmen Garrido

Olivier Hermine

Geneviève Courtois

机构：

[1] Laboratoire INSERM,Département de Biothérapie

[2] unité mixte de recherche 1163,undefined

[3] centre national de la recherche scientifique (CNRS) équipe de recherche labellisée 8254,undefined

[4] 24 Boulevard de Montparnasse,undefined

[5] 75015 Paris,undefined

[6] France,undefined

[7] Service de Médecine Interne,undefined

[8] Faculté de médecine Paris Descartes,undefined

[9] Sorbonne Paris-Cité et Assistance publique – Hôpitaux de Paris,undefined

[10] Hôpital Européen Georges Pompidou,undefined

[11] 15 rue Leblanc 75908 Paris,undefined

[12] France,undefined

[13] Paris Descartes-Sorbonne Paris Cité University,undefined

[14] Imagine Institute,undefined

[15] Assistance publique – Hôpitaux de Paris,undefined

[16] Hôpital Necker,undefined

[17] 24 Boulevard de Montparnasse,undefined

[18] 75015 Paris,undefined

[19] France,undefined

[20] Laboratory of Excellence GR-Ex,undefined

[21] 75015 Paris,undefined

[22] France,undefined

[23] Faculté de médecine Paris Descartes,undefined

[24] Sorbonne Paris-Cité et Assistance publique – Hôpitaux de Paris,undefined

[25] Hôpital Necker,undefined

[26] 149 rue de Sèvres 75015 Paris,undefined

[27] France,undefined

[28] Commissariat à l’énergie atomique (CEA),undefined

[29] Institute of Emerging Diseases and Innovative Therapies (iMETI),undefined

[30] 18 Route du Panorama,undefined

[31] 92260 Fontenay-aux-Roses,undefined

[32] France,undefined

[33] INSERM,undefined

[34] unité mixte de recherche 866,undefined

[35] Equipe labellisée Ligue contre le Cancer and Association pour la Recherche contre le Cancer,undefined

[36] and Laboratoire d’Excellence Lipoprotéines et santé (LipSTIC),undefined

[37] 21033 Dijon,undefined

[38] France,undefined

[39] University of Burgundy,undefined

[40] Faculty of Medicine and Pharmacy,undefined

[41] 7 boulevard Jeanne d'Arc,undefined

[42] 21033 Dijon,undefined

[43] France,undefined

[44] INSERM,undefined

[45] unité mixte de recherche 699,undefined

[46] Hôpital Bichat,undefined

[47] 46 rue Henri Huchard,undefined

[48] 75018 Paris,undefined

[49] France,undefined

[50] Faculté de médecine and Université Denis Diderot Paris VII,undefined

来源：

Nature | 2014年 / 514卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

In human β-thalassaemiaerythroblasts, HSP70 is sequestered in the cytoplasm by the excess of free α-globin chains and can no longer protect the master transcriptional factor of erythropoiesis GATA-1 from caspase-3 cleavage; transduction of a nuclear-targeted HSP70 or a caspase-3 uncleavable GATA-1 mutant restored maturation of erythropoiesis.

引用

页码：242 / 246

页数：4

共 50 条

[1] HSP70 sequestration by free α-globin promotes ineffective erythropoiesis in β-thalassaemia
Arlet, Jean-Benoit
Ribeil, Jean-Antoine
Guillem, Flavia
Negre, Olivier
Hazoume, Adonis
Marcion, Guillaume
Beuzard, Yves
Dussiot, Michael
Moura, Ivan Cruz
Demarest, Samuel
de Beauchene, Isaure Chauvot
Belaid-Choucair, Zakia
Sevin, Margaux
Maciel, Thiago Trovati
Auclair, Christian
Leboulch, Philippe
Chretien, Stany
Tchertanov, Luba
Baudin-Creuza, Veronique
Seigneuric, Renaud
Fontenay, Michaela
Garrido, Carmen
Hermine, Olivier
Courtois, Genevieve
NATURE, 2014, 514 (7521) : 242 - +
[2] HSP70 regulates ineffective erythropoiesis in beta-thalassaemia
Arlet, Jean-Benoit
Ribeil, Jean-Antoine
Guillem, Flavia
Hermine, Olivier
Courtois, Genevieve
M S-MEDECINE SCIENCES, 2015, 31 (01): : 9 - 11
[3] Heat Shock Protein 70 Cytosolic Sequestration by Excess of Free Alpha-Globin Chains Is a Key Mechanism of the Ineffective Erythropoiesis in β-Thalassemia Major Patients
Arlet, Jean-Benoit
Ribeil, Jean-Antoine
Hazoume, Adonis
Demarest, Samuel
Tchertanov, Luba
Michael, Dussiot
Moura, Ivan Cruz
Maciel, Thiago
Auclair, Christian
Negre, Olivier
Leboulch, Philippe
Baudin-creuza, Veronique
Garrido, Carmen
Courtois, Genevieve
Hermine, Olivier
BLOOD, 2012, 120 (21)
[4] HSP70 promotes MLKL polymerization and necroptosis
Johnston, Andrea N.
Wang, Zhigao
MOLECULAR & CELLULAR ONCOLOGY, 2020, 7 (05)
[5] HSP70 Is Increased in Circulating Extracellular Vesicles from Transfusion-Dependent β-Thalassemia Patients: Potential Biomarker for Ineffective Erythropoiesis
Levin, Carina
Rebibo-Sabbah, Annie
Koren, Ariel
Brenner, Benjamin
Aharon, Anat
BLOOD, 2016, 128 (22)
[6] Hsp70 promotes the proteolysis of oxidatively damaged proteins
Reeg, Sandra
Grune, Tilman
FREE RADICAL BIOLOGY AND MEDICINE, 2015, 86 : S30 - S30
[7] Thermal pretreatment promotes the protective effect of HSP70 against tendon adhesion in tendon healing by increasing HSP70 expression
Tang, Xiao-Ming
Dai, Jian
Sun, Hai-Lang
MOLECULAR MEDICINE REPORTS, 2019, 20 (01) : 205 - 215
[8] Sulfatide-Hsp70 Interaction Promotes Hsp70 Clustering and Stabilizes Binding to Unfolded Protein
Harada, Yoichiro
Sato, Chihiro
Kitajima, Ken
BIOMOLECULES, 2015, 5 (02): : 958 - 973
[9] Hsp70 Promotes ENaC Functional Expression and Association with COPII
Chanoux, Rebecca A.
Robay, Amal
Chang, Tina Chi-Chun
Rubenstein, Ronald C.
FASEB JOURNAL, 2011, 25
[10] HSP70 PROMOTES ENAC FUNCTIONAL EXPRESSION AND ASSOCIATION WITH THE COPII COMPLEX
Chanoux, R.
Shubin, C.
Robay, A.
Rubenstein, R. C.
PEDIATRIC PULMONOLOGY, 2011, : 242 - 243

← 1 2 3 4 5 →