Update on the management of pancreatic cancer: Determinants for surgery and widening the therapeutic window of surgical resection

Purpose of Review Pancreatic cancer continues to be a disease associated with poor long-term survival. Surgical resection is associated with high morbidity and delays in systemic therapy. Recent Findings Recognition of pancreatic cancer as a systemic disease has led to the increased utilization of mul-timodality therapy and shifting paradigms in the sequence of care. Identification of biomarkers and improved under-standing of tumor biology have allowed for improved patient stratification and an individualized approach to treatment planning. Additionally, introduction of minimally invasive approaches to pancreatic resection have improved rates of significant post-operative morbidity. Summary Cumulatively, these new developments have altered the approach to surgical resection and aid in improving patient survival. © Springer Science + Business Media New York 2016.