25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner

被引：0
|
作者：
Man Ying Wong
Michael Lewis
James J. Doherty
Yang Shi
Anil G. Cashikar
Anna Amelianchik
Svitlana Tymchuk
Patrick M. Sullivan
Mingxing Qian
Douglas F. Covey
Gregory A. Petsko
David M. Holtzman
Steven M. Paul
Wenjie Luo
机构：
[1] Weill Cornell Medicine,Appel Alzheimer’s Disease Research Institute, Feil Family Brain and Mind Research Institute
[2] Sage Therapeutics,Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer’s Disease Research Center
[3] Washington University School of Medicine,Department of Medicine, Duke University Medical Center
[4] Durham Veterans Health Administration Medical Center’s Geriatric Research,Departments of Developmental Biology, Anesthesiology, Taylor Family Institute for Innovative Psychiatric Research
[5] Education and Clinical Center,Departments of Neurology and Psychiatry, Hope Center for Neurological Disorders, Taylor Family Institute
[6] Washington University in St. Louis,undefined
[7] Washington University School of Medicine,undefined
来源：
Journal of Neuroinflammation | / 17卷
关键词：
Alzheimer’s disease; Microglia; Inflammation; Lipid metabolism; Apolipoprotein E; Interleukin-1β; Cholesterol 25-hydroxylase; Oxysterol; 25-Hydroxycholesterol; Lipopolysaccharide; Inflammasome;
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