Antidepressant Properties of Proproten and Amitriptyline: Comparative Experimental Study

被引：3
|
作者：
O. I. Epstein
G. M. Molodavkin
T. A. Voronina
S. A. Sergeeva
机构：
[1] “Materia Medica Holding” Research-and-Production Company,
来源：
Bulletin of Experimental Biology and Medicine | 2003年 / 135卷 / Suppl 7期
关键词：
antibodies against S100 protein; ultralow doses; Proproten; antidepressant activity; amitriptyline; behavioral helplessness; swimming in reservoir with wheels;
D O I：
10.1023/A:1024724023144
中图分类号：
学科分类号：
摘要：
Antidepressant properties of Proproten (antibodies to S100 protein in ultralow doses) were studied on outbred albino rats. The animals were subjected to the Porsolt's test of behavioral helplessness and Nomura's test of forced swimming in a reservoir with freely rotating wheels. Proproten in a dose of 2.5 ml/kg produced a strong antidepressant effect. It was observed after single and repeated (5 days) peroral treatment with the preparation. Proproten decreased the immobility time (Porsolt's test) and increased the number of wheel turns (Nomura's test). The activity of Proproten compared well with the standard preparation amitriptyline. As differentiated from amitriptyline, Proproten did not produce the sedative effect.
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页码：123 / 124
页数：1
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