Ocular pharmacokinetics of verapamil in rabbits

被引：0
|
作者：
A. Ettl
U. Hofmann
Albert Daxer
Hermann Dietrich
Eduard Schmid
Michel Eichelbaum
机构：
[1] Allgemeines Krankenhaus,
[2] P. O. Box 176,undefined
[3] A-3100 St. Pölten,undefined
[4] Austria,undefined
[5] Department of Ophthalmology,undefined
[6] University of Innsbruck,undefined
[7] Innsbruck,undefined
[8] Austria,undefined
[9] Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology,undefined
[10] Stuttgart,undefined
[11] Germany,undefined
[12] Central Laboratory Animal Facilities,undefined
[13] University of Innsbruck,undefined
[14] Innsbruck,undefined
[15] Austria,undefined
来源：
Naunyn-Schmiedeberg's Archives of Pharmacology | 1998年 / 357卷
关键词：
Key words Verapamil; Pharmacokinetics; Eye; Cataract; Glaucoma;
D O I：
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中图分类号：
学科分类号：
摘要：
Previously, it had been demonstrated that cataract in diabetic rats can be prevented by systemical administration of the calcium channel blocker verapamil. In addition to that, 0.125% verapamil eye drops were found to significantly reduce the intraocular pressure in ocular hypertensive human subjects. The purpose of this study was to investigate the ocular penetration and elimination of verapamil after topical administration of the drug in rabbits. Two drops of a 0.125% aqueous solution of RS-verapamil hydrochloride (corresponding to a total dose of 125 μg RS-verapamil hydrochloride) were administered into the conjunctival sac. Aqueous humor and blood samples were taken at different times after administration and analysed for drug concentration by combined gas chromatography-mass spectroscopy.
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页码：331 / 335
页数：4
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