Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators

被引：0

作者：

David Landeira

Stephan Sauer

Raymond Poot

Maria Dvorkina

Luca Mazzarella

Helle F. Jørgensen

C. Filipe Pereira

Marion Leleu

Francesco M. Piccolo

Mikhail Spivakov

Emily Brookes

Ana Pombo

Cynthia Fisher

William C. Skarnes

Tim Snoek

Karel Bezstarosti

Jeroen Demmers

Robert J. Klose

Miguel Casanova

Ligia Tavares

Neil Brockdorff

Matthias Merkenschlager

Amanda G. Fisher

机构：

[1] Lymphocyte Development Group,Department of Cell Biology

[2] MRC Clinical Sciences Centre,Epigenetic Regulation of Chromatin Function Group Department of Biochemistry

[3] Imperial College School of Medicine,Department of Biochemistry

[4] Hammersmith Hospital Campus,undefined

[5] Erasmus Medical Centre,undefined

[6] Genome Function Group,undefined

[7] MRC Clinical Sciences Centre,undefined

[8] Imperial College School of Medicine,undefined

[9] Hammersmith Hospital Campus,undefined

[10] Mouse Developmental Genetics Group,undefined

[11] Wellcome Trust Sanger Institute,undefined

[12] Wellcome Trust Genome Campus,undefined

[13] Proteomics Center,undefined

[14] Erasmus Medical Centre,undefined

[15] University of Oxford,undefined

[16] Developmental Epigenetics Group,undefined

[17] University of Oxford,undefined

来源：

Nature Cell Biology | 2010年 / 12卷

关键词：

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学科分类号：

摘要：

Fisher and colleagues find that Jarid2 is a subunit of PRC2 (Polycomb Repressor Complex 2) that recruits PRC1 complex and Ser 5-phosphorylated RNA Polymerase II to developmental regulators in embryonic stem (ES) cells. Jarid2-deficient ES cells do not efficiently differentiate to mesoderm or neural lineages in vitro.

引用

页码：618 / 624

页数：6

共 28 条

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