Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators

被引：0
|
作者：
David Landeira
Stephan Sauer
Raymond Poot
Maria Dvorkina
Luca Mazzarella
Helle F. Jørgensen
C. Filipe Pereira
Marion Leleu
Francesco M. Piccolo
Mikhail Spivakov
Emily Brookes
Ana Pombo
Cynthia Fisher
William C. Skarnes
Tim Snoek
Karel Bezstarosti
Jeroen Demmers
Robert J. Klose
Miguel Casanova
Ligia Tavares
Neil Brockdorff
Matthias Merkenschlager
Amanda G. Fisher
机构：
[1] Lymphocyte Development Group,Department of Cell Biology
[2] MRC Clinical Sciences Centre,Epigenetic Regulation of Chromatin Function Group Department of Biochemistry
[3] Imperial College School of Medicine,Department of Biochemistry
[4] Hammersmith Hospital Campus,undefined
[5] Erasmus Medical Centre,undefined
[6] Genome Function Group,undefined
[7] MRC Clinical Sciences Centre,undefined
[8] Imperial College School of Medicine,undefined
[9] Hammersmith Hospital Campus,undefined
[10] Mouse Developmental Genetics Group,undefined
[11] Wellcome Trust Sanger Institute,undefined
[12] Wellcome Trust Genome Campus,undefined
[13] Proteomics Center,undefined
[14] Erasmus Medical Centre,undefined
[15] University of Oxford,undefined
[16] Developmental Epigenetics Group,undefined
[17] University of Oxford,undefined
来源：
Nature Cell Biology | 2010年 / 12卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Fisher and colleagues find that Jarid2 is a subunit of PRC2 (Polycomb Repressor Complex 2) that recruits PRC1 complex and Ser 5-phosphorylated RNA Polymerase II to developmental regulators in embryonic stem (ES) cells. Jarid2-deficient ES cells do not efficiently differentiate to mesoderm or neural lineages in vitro.
引用
收藏
页码：618 / 624
页数：6
相关论文
共 28 条
  • [1] Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators
    Landeira, David
    Sauer, Stephan
    Poot, Raymond
    Dvorkina, Maria
    Mazzarella, Luca
    Jorgensen, Helle F.
    Pereira, C. Filipe
    Leleu, Marion
    Piccolo, Francesco M.
    Spivakov, Mikhail
    Brookes, Emily
    Pombo, Ana
    Fisher, Cynthia
    Skarnes, William C.
    Snoek, Tim
    Bezstarosti, Karel
    Demmers, Jeroen
    Klose, Robert J.
    Casanova, Miguel
    Tavares, Ligia
    Brockdorff, Neil
    Merkenschlager, Matthias
    Fisher, Amanda G.
    NATURE CELL BIOLOGY, 2010, 12 (06) : 618 - U214
  • [2] PRC1 and PRC2 Are Not Required for Targeting of H2A.Z to Developmental Genes in Embryonic Stem Cells
    Illingworth, Robert S.
    Botting, Catherine H.
    Grimes, Graeme R.
    Bickmore, Wendy A.
    Eskeland, Ragnhild
    PLOS ONE, 2012, 7 (04):
  • [3] PRC1 and PRC2 proximal interactome in mouse embryonic stem cells
    Zijlmans, Authors Dick W.
    Stelloo, Suzan
    Bax, Danique
    Yordanov, Yavor
    Toebosch, Pien
    Raas, Maximilian W. D.
    Verhelst, Sigrid
    Lamers, Lieke A.
    Baltissen, Marijke P. A.
    Jansen, Pascal W. T. C.
    van Mierlo, Guido
    Dhaenens, Maarten
    Marks, Hendrik
    Vermeulen, Michiel
    CELL REPORTS, 2025, 44 (03):
  • [4] THE PRC2 COMPONENT JARID2 IS DISPENSABLE FOR HEMATOPOIETIC STEM CELLS, BUT CRITICAL FOR MAINTENANCE OF LEUKEMIC STEM CELLS
    Frank, Anne-Katrine
    Willer, Anton
    Jensen, Tanja Lyholm
    D'Altri, Teresa
    Rapin, Nicolas
    Lauridsen, Felicia Kathrine Bratt
    Wilhelmson, Anna Sofia Katarina
    Ge, Ying
    Pundir, Sachin
    Hasemann, Marie
    Helin, Kristian
    Porse, Bo
    EXPERIMENTAL HEMATOLOGY, 2016, 44 (09) : S47 - S47
  • [5] THE PRC2 COMPONENT JARID2 IS DISPENSABLE FOR HEMATOPOIETIC STEM CELLS BUT CRITICAL FOR THE MAINTENANCE OF LEUKEMIC STEM CELLS
    Frank, A. K.
    Willer, A.
    Jensen, T. L.
    Rapin, N.
    Lauridsen, F. K. B.
    D'Altri, T.
    Wilhelmson, A.
    Ge, Y.
    Pundir, S.
    Hasemann, M.
    Helin, K.
    Porse, B.
    HAEMATOLOGICA, 2016, 101 : 117 - 117
  • [6] Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2
    Sarah Cooper
    Anne Grijzenhout
    Elizabeth Underwood
    Katia Ancelin
    Tianyi Zhang
    Tatyana B. Nesterova
    Burcu Anil-Kirmizitas
    Andrew Bassett
    Susanne M. Kooistra
    Karl Agger
    Kristian Helin
    Edith Heard
    Neil Brockdorff
    Nature Communications, 7
  • [7] Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2
    Cooper, Sarah
    Grijzenhout, Anne
    Underwood, Elizabeth
    Ancelin, Katia
    Zhang, Tianyi
    Nesterova, Tatyana B.
    Anil-Kirmizitas, Burcu
    Bassett, Andrew
    Kooistra, Susanne M.
    Agger, Karl
    Helin, Kristian
    Heard, Edith
    Brockdorff, Neil
    NATURE COMMUNICATIONS, 2016, 7
  • [8] Mir-128 CONTROLS THE ACTIVITY OF EPIGENETIC REGULATORS PRC1 AND PRC2 IN NEURAL STEM CELLS: IMPLICATIONS OF ITS LOSS IN GLIOMAGENESIS
    Peruzzi, Pierpaolo
    Chiocca, E. Antonio
    Godlewski, Jakub
    NEURO-ONCOLOGY, 2013, 15 : 25 - 25
  • [9] Cell Signaling Coordinates Global PRC2 Recruitment and Developmental Gene Expression in Murine Embryonic Stem Cells
    Aljazi, Mohammad B.
    Gao, Yuen
    Wu, Yan
    Mias, George, I
    He, Jin
    ISCIENCE, 2020, 23 (11)
  • [10] Two Functional Axes of Feedback-Enforced PRC2 Recruitment in Mouse Embryonic Stem Cells
    Perino, Matteo
    van Mierlo, Guido
    Loh, Chet
    Wardle, Sandra M. T.
    Zijlmans, Dick W.
    Marks, Hendrik
    Veenstra, Gert Jan C.
    STEM CELL REPORTS, 2020, 15 (06): : 1287 - 1300
123