The Antiarrhythmic and Anticonvulsant Effects of Dietary N-3 Fatty Acids

被引：0

作者：

A. Leaf

J.X. Kang

Y-F. Xiao

G.E. Billman

R.A. Voskuyl

机构：

[1] Departments of Medicine,

[2] Massachusetts General Hospital,undefined

[3] Bldg 149,undefined

[4] 13th Street,undefined

[5] Charlestown,undefined

[6] MA 02129,undefined

[7] USA,undefined

[8] Beth Israel Deaconess Medical Center and Harvard Medical School,undefined

[9] Boston,undefined

[10] MA 02215,undefined

[11] USA,undefined

[12] Department of Physiology,undefined

[13] The Ohio State University,undefined

[14] Columbus,undefined

[15] OH 45210,undefined

[16] USA,undefined

[17] Department of Physiology,undefined

[18] Leiden University Medical Center,undefined

[19] and the Stichting Epilepsie Instellingen Nederland,undefined

[20] P.O. Box 21,undefined

[21] 2100 AA Heemstede,undefined

[22] The Netherlands,undefined

来源：

The Journal of Membrane Biology | 1999年 / 172卷

关键词：

Key words: Omega-3 — n-3 — Omega-6 — n-6 — Eicosapentaenoic acid — Docosahexaenoic acid — Arrhythmias — Seizures;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

It has been shown in animals and probably in humans, that n-3 polyunsaturated fatty acids (PUFAs) are antiarrhythmic. We report recent studies on the antiarrhythmic actions of PUFAs. The PUFAs stabilize the electrical activity of isolated cardiac myocytes by modulating sarcolemmal ion channels, so that a stronger electrical stimulus is required to elicit an action potential and the refractory period is markedly prolonged. Inhibition of voltage-dependent sodium currents, which initiate action potentials in excitable tissues, and of the L-type calcium currents, which initiate release of sarcoplasmic calcium stores that increase cytosolic free calcium concentrations and activate the contractile proteins in myocytes, appear at present to be the probable major antiarrhythmic mechanism of the PUFAs.

引用

页码：1 / 11

页数：10

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