TCR avidity: it's not how strong you make it, it's how you make it strong

被引:0
|
作者
David H. Margulies
机构
[1] Molecular Biology Section,
[2] Laboratory of Immunology,undefined
[3] NIAID,undefined
[4] National Institutes of Health,undefined
来源
Nature Immunology | 2001年 / 2卷
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摘要
Unlike the BCR, the TCR cannot undergo affinity maturation. However, T cells respond with greater sensitivity to antigen during an immune response. New evidence suggests T cells undergo avidity maturation to enhance T cell responsiveness in the absence of changes in intrinsic affinity.
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页码:669 / 670
页数:1
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