TCR avidity: it's not how strong you make it, it's how you make it strong

被引：30

作者：

Margulies, DH ^{[1
]}

机构：

[1] NIAID, Mol Biol Sect, Immunol Lab, Bethesda, MD 20892 USA

来源：

NATURE IMMUNOLOGY | 2001年 / 2卷 / 08期

关键词：

D O I：

10.1038/90601

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Unlike the BCR, the TCR cannot undergo affinity maturation. However T cells respond with greater sensitivity to antigen during an immune response. New evidence suggests T cells undergo avidity maturation to enhance T cell responsiveness in the absence of changes in intrinsic affinity.

引用

页码：669 / 670

页数：2

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