Secreted and O-GlcNAcylated MIF binds to the human EGF receptor and inhibits its activation

被引：0

作者：

Yanhua Zheng

Xinjian Li

Xu Qian

Yugang Wang

Jong-Ho Lee

Yan Xia

David H. Hawke

Gang Zhang

Jianxin Lyu

Zhimin Lu

机构：

[1] The University of Texas MD Anderson Cancer Center,Department of Neuro

[2] The University of Texas MD Anderson Cancer Center,Oncology

[3] Affiliated Hospital of Hebei University,Department of Systems Biology

[4] Key Laboratory of Laboratory Medicine,Department of Surgical Oncology

[5] Ministry of Education,Department of Molecular and Cellular Oncology

[6] Zhejiang Provincial Key Laboratory of Medical Genetics,undefined

[7] School of Laboratory Medicine and Life Sciences,undefined

[8] Wenzhou Medical University,undefined

[9] The University of Texas MD Anderson Cancer Center,undefined

[10] Cancer Biology Program,undefined

[11] The University of Texas Graduate School of Biomedical Sciences at Houston,undefined

来源：

Nature Cell Biology | 2015年 / 17卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Lu and colleagues report that the O-GlcNAcylated MIF cytokine binds the extracellular domain of EGFR and prevents EGF-induced EGFR activation. Conversely, EGFR activation leads to MMP13-mediated MIF degradation and EGFR-induced tumorigenesis

引用

页码：1348 / 1355

页数：7

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