Genome-Wide Searches for Bipolar Disorder Genes

被引：0
|
作者：
Shaza Alsabban
Margarita Rivera
Peter McGuffin
机构：
[1] MRC Social,
[2] Genetic,undefined
[3] and Developmental Psychiatry Centre,undefined
[4] Institute of Psychiatry,undefined
[5] King’s College London,undefined
来源：
Current Psychiatry Reports | 2011年 / 13卷
关键词：
Bipolar disorder; Genes; Whole-genome linkage; Whole-genome association; Copy number variants; CNV; Pathway analysis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Whole-genome linkage and association studies of bipolar disorder are beginning to provide some compelling evidence for the involvement of several chromosomal regions and susceptibility genes in the pathogenesis of bipolar disorder. Developments in genotyping technology and efforts to combine data from different studies have helped in identifying chromosomes 6q16-q25, 13q, and 16p12 as probable susceptibility loci for bipolar disorder and confirmed CACNA1C and ANK3 as susceptibility genes for bipolar disorder. However, a lack of replication is still apparent in the literature. New studies focusing on copy number variants as well as new analytical approaches utilizing pathway analysis offer a new direction in the study of the genetics of bipolar disorder.
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页码：522 / 527
页数：5
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