The role of TGF-β1 in mice hepatic fibrosis bySchistosomiasis Japonica

被引：0
|
作者：
Zhu Huabin
Zeng Linglan
Zhu Dahe
Yuan Yonghui
机构：
[1] Tongji Medical University,Department of Infectious Disease, Xiehe Hospital
[2] Tongji Medical University,Department of Pathology
来源：
Current Medical Science | 2000年 / 20卷 / 4期
关键词：
transforming growth factor-β; hepatic fibrosis;
D O I：
10.1007/BF02888191
中图分类号：
学科分类号：
摘要：
To investigate the role of transforming growth factor-β1 (TGF-β1) in mice with hepatic fibrosis caused bySchistosomiasis Japonica, ELISA, VG staining and multimedia color hieroglyph quantitative analysis were used to study the change of the serum TGF-β1, liver collagen fiber and reticular fiber in mice. The level of serum TGF-β1 in experimental group was significantly higher than that in control group (P < 0. 01 orP < 0. 05) 8, 10, 12 weeks after infected by schistosomiasis. After infection, the level of liver collagen fiber and reticular fiber, and that of TGF -β1 increased over time (P < 0. 01 orP < 0. 05). In mice infected bySchistosomiasis Japonica, the level of TGF-β1 increased with prolongation of infection time, and with the increase of liver collagen fiber and reticular fiber. TGFβ1 plays an important role of immunomodulation in hepatic fibrosis formation caused bySchistosomiasis Japonica.
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页码：320 / 321
页数：1
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