Effects of CYP1A2 Gene Polymorphisms on Antipyrine CYP1A2-Dependent Metabolism

被引：0
|
作者：
Yu. I. Chernyak
V. B. Itskovich
S. I. Kolesnikov
机构：
[1] the Siberian Division of the Russian Academy of Medical Sciences,Angarsk Affiliated Department of East Siberian Center of Human Ecology
来源：
Bulletin of Experimental Biology and Medicine | 2011年 / 151卷
关键词：
genetic polymorphism; cytochrome P-4501A2; metabolism; antipyrine; cotinine;
D O I：
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学科分类号：
摘要：
The distribution of two CYP1A2 gene polymorphisms, CYP1A2*F and CYP1A2*D, was studied in a group of 38 men. Antipyrine elimination test was carried out and urinary cotinine was measured. The contribution of these CYP1A2 gene polymorphisms, age, and tobacco smoking to accumulation of three main antipyrine metabolites in the urine was evaluated by regression analysis. The impact of both studied polymorphisms was essential for urinary levels of 3-hydroxymethylantipyrine (metabolite most dependent on cytochrome P-4501A2) and hence, for functional activity of this isoform of the enzyme.
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页码：445 / 448
页数：3
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