Effects of CYP1A2 Gene Polymorphisms on Antipyrine CYP1A2-Dependent Metabolism

被引：0
|
作者：
Yu. I. Chernyak
V. B. Itskovich
S. I. Kolesnikov
机构：
[1] the Siberian Division of the Russian Academy of Medical Sciences,Angarsk Affiliated Department of East Siberian Center of Human Ecology
来源：
Bulletin of Experimental Biology and Medicine | 2011年 / 151卷
关键词：
genetic polymorphism; cytochrome P-4501A2; metabolism; antipyrine; cotinine;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The distribution of two CYP1A2 gene polymorphisms, CYP1A2*F and CYP1A2*D, was studied in a group of 38 men. Antipyrine elimination test was carried out and urinary cotinine was measured. The contribution of these CYP1A2 gene polymorphisms, age, and tobacco smoking to accumulation of three main antipyrine metabolites in the urine was evaluated by regression analysis. The impact of both studied polymorphisms was essential for urinary levels of 3-hydroxymethylantipyrine (metabolite most dependent on cytochrome P-4501A2) and hence, for functional activity of this isoform of the enzyme.
引用
收藏
页码：445 / 448
页数：3
相关论文
共 50 条
  • [1] Effects of CYP1A2 Gene Polymorphisms on Antipyrine CYP1A2-Dependent Metabolism
    Chernyak, Yu. I.
    Itskovich, V. B.
    Kolesnikov, S. I.
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2011, 151 (04) : 445 - 448
  • [2] Polymorphisms in the CYP1A2 gene and theophylline metabolism in patients with asthma
    Obase, Y
    Shimoda, T
    Kawano, T
    Saeki, S
    Tomari, S
    Mitsuta-Izaki, K
    Matsuse, H
    Kinoshita, M
    Kohno, S
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2003, 73 (05) : 468 - 474
  • [3] Effect of venlafaxine on CYP1A2-dependent pharmacokinetics and metabolism of caffeine
    Amchin, J
    Zarycranski, W
    Taylor, KP
    Albano, D
    Klockowski, PM
    JOURNAL OF CLINICAL PHARMACOLOGY, 1999, 39 (03): : 252 - 259
  • [4] CYP1A1/CYP1A2 polymorphisms and colorectal cancer
    Ozhan, Gul
    Mutur, Mine
    TOXICOLOGY LETTERS, 2012, 211 : S69 - S69
  • [5] Detailed modelling of caffeine metabolism and examination of the CYP1A2 gene:: lack of a polymorphism in CYP1A2 in Caucasians
    Welfare, MR
    Aitkin, M
    Bassendine, MF
    Daly, AK
    PHARMACOGENETICS, 1999, 9 (03): : 367 - 375
  • [6] Evaluation of the influence of diabetes mellitus on antipyrine metabolism and CYP1A2 and CYP2D6 activity
    Matzke, GR
    Frye, RF
    Early, JJ
    Straka, RJ
    Carson, SW
    PHARMACOTHERAPY, 2000, 20 (02): : 182 - 190
  • [7] CYP1A1, CYP1A2 and CYBA gene polymorphisms associated with oxidative stress in COPD
    Vibhuti, Arpana
    Arif, Ehtesham
    Mishra, Aastha
    Deepak, Desh
    Singh, Bhawani
    Rahman, Irfan
    Mohammad, Ghulam
    Pasha, M. A. Qadar
    CLINICA CHIMICA ACTA, 2010, 411 (7-8) : 474 - 480
  • [8] CYP1A2 polymorphisms and clozapine metabolism in Chinese psychotic patients
    Chen, J. Y.
    Chen, T. T.
    Liou, Y. J.
    Yen, C. F.
    Chang, W. H.
    EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2007, 17 : S481 - S482
  • [9] The effect of CYP1A2 gene polymorphism on the metabolism of theophylline
    Xiong, Shijuan
    Li, Lingling
    EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2018, 15 (01) : 109 - 114
  • [10] CYP1A2, GSTM1, and GSTT1 Polymorphisms and Diet Effects on CYP1A2 Activity in a Crossover Feeding Trial
    Peterson, Sabrina
    Schwarz, Yvonne
    Li, Shuying S.
    Li, Lin
    King, Irena B.
    Chen, Chu
    Eaton, David L.
    Potter, John D.
    Lampe, Johanna W.
    CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2009, 18 (11) : 3118 - 3125
12345