CD8+ T cell development: CD4 to the rescue

被引：0
|
作者：
H. Robson MacDonald
Werner Held
机构：
[1] Ludwig Institute for Cancer Research,
[2] Lausanne Branch,undefined
[3] University of Lausanne,undefined
来源：
Nature Immunology | 2001年 / 2卷
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摘要：
How immature CD4+CD8+ thymocytes become committed to either the CD4 (helper) or CD8 (cytotoxic) lineage is controversial. Genetic ablation of a silencer element in the gene encoding CD4 provides new evidence that CD8 lineage commitment occurs via a stochastic, rather than instructive, mechanism.
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页码：1091 / 1092
页数：1
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