CD8+ T cell development: CD4 to the rescue

被引：0
|
作者：
H. Robson MacDonald
Werner Held
机构：
[1] Ludwig Institute for Cancer Research,
[2] Lausanne Branch,undefined
[3] University of Lausanne,undefined
来源：
Nature Immunology | 2001年 / 2卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
How immature CD4+CD8+ thymocytes become committed to either the CD4 (helper) or CD8 (cytotoxic) lineage is controversial. Genetic ablation of a silencer element in the gene encoding CD4 provides new evidence that CD8 lineage commitment occurs via a stochastic, rather than instructive, mechanism.
引用
收藏
页码：1091 / 1092
页数：1
相关论文
共 50 条
  • [1] CD8+ T cell development:: CD4 to the rescue
    MacDonald, HR
    Held, W
    [J]. NATURE IMMUNOLOGY, 2001, 2 (12) : 1091 - 1092
  • [2] Heterospecific CD4 Help to Rescue CD8 T Cell Killers
    de Herve, Marie-Ghislaine de Goer
    Cariou, Anne
    Simonetta, Federico
    Taoufik, Yassine
    [J]. JOURNAL OF IMMUNOLOGY, 2008, 181 (09): : 5974 - 5980
  • [3] Notch signaling in CD4 and CD8 T cell development
    Laky, Karen
    Fowkes, B. J.
    [J]. CURRENT OPINION IN IMMUNOLOGY, 2008, 20 (02) : 197 - 202
  • [4] Upregulation of CD4 on CD8+ T cells:: CD4dimCD8bright T cells constitute an activated phenotype of CD8+ T cells
    Sullivan, YB
    Landay, AL
    Zack, JA
    Kitchen, SG
    Al-Harthi, L
    [J]. IMMUNOLOGY, 2001, 103 (03) : 270 - 280
  • [5] The molecular basis of CD4 help during CD8+ T cell memory formation
    Cullen, J.
    Olshansky, M.
    Turner, S.
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 2016, 46 : 979 - 979
  • [6] Differential effects of CD4 and CD8 engagement on the development of cytokine profiles of murine CD4+ and CD8+ T lymphocytes
    Campbell, SB
    Komata, T
    Kelso, A
    [J]. IMMUNOLOGY, 2000, 99 (03) : 394 - 401
  • [7] CD8 T cell memory development: CD4 T cell help is appreciated
    Khanolkar, Aaruni
    Badovinac, Vladimir P.
    Harty, John T.
    [J]. IMMUNOLOGIC RESEARCH, 2007, 39 (1-3) : 94 - 104
  • [8] CD8 T cell memory development: CD4 T cell help is appreciated
    Aaruni Khanolkar
    Vladimir P. Badovinac
    John T. Harty
    [J]. Immunologic Research, 2007, 39 : 94 - 104
  • [9] T-cell development and the CD4–CD8 lineage decision
    Ronald N. Germain
    [J]. Nature Reviews Immunology, 2002, 2 : 309 - 322
  • [10] Memory programming in CD8+ T-cell differentiation is intrinsic and is not determined by CD4 help
    Kim, Juhyun
    Ryu, Su Jeong
    Oh, Keunhee
    Ju, Ji-Min
    Jeon, Ji Yeong
    Nam, Giri
    Lee, Dong-Sup
    Kim, Hang-Rae
    Kim, Joo Young
    Chang, Jun
    Sproule, Thomas
    Choi, Kyungho
    Roopenian, Derry
    Choi, Eun Young
    [J]. NATURE COMMUNICATIONS, 2015, 6
12345