Synthesis of 2,5-di(hydroxyalkyl)-1,3-thiazoles

被引：0
|
作者：
V. O. Sinenko
S. R. Slivchuk
Ya. G. Bal’on
V. S. Brovarets
机构：
[1] National Academy of Sciences of Ukraine,Institute of Bioorganic Chemistry and Petrochemistry
[2] National Academy of Medical Science,Komisarenko Institute of Endocrinology and Metabolism
来源：
Russian Journal of General Chemistry | 2015年 / 85卷
关键词：
1,3-thiazole; -butyllithium; electrophile; diol;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A general approach towards synthesis of 2(5)-hydroxyalkyl-substituted 1,3-thiazole derivatives has been proposed. The method includes lithiation of 1,3-thiazole ring followed by reacting the formed thiazole lithium derivatives with electrophiles.
引用
收藏
页码：1855 / 1861
页数：6
相关论文
共 50 条
  • [1] Synthesis of 2,5-di(hydroxyalkyl)-1,3-thiazoles
    Sinenko, V. O.
    Slivchuk, S. R.
    Bal'on, Ya. G.
    Brovarets, V. S.
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2015, 85 (08) : 1855 - 1861
  • [2] Synthesis of 2-aryl-2-(trifluoromethyl)-2,5-dihydro-1,3-thiazoles
    Bentya, A. V.
    Mel'nichenko, N. V.
    Vovk, M. V.
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2016, 52 (02) : 292 - 293
  • [3] Synthesis of 2-aryl-2-(trifluoromethyl)-2,5-dihydro-1,3-thiazoles
    A. V. Bentya
    N. V. Mel’nichenko
    M. V. Vovk
    Russian Journal of Organic Chemistry, 2016, 52 : 292 - 293
  • [4] EFFICIENT SYNTHESIS OF 2-SUBSTITUTED 1,3-THIAZOLES
    DUBS, P
    PESARO, M
    SYNTHESIS-STUTTGART, 1974, (04): : 294 - 295
  • [5] SYNTHESIS OF 4,5-DIPHENYL-2-METHYLTHIO-1,3-THIAZOLE THROUGH DIASTEROMETRIC 2,5-DI(METHYLTHIO)-4,5-DIPHENYL-4,5-DIHYDRO-1,3-THIAZOLES
    ALVAREZBARRA, C
    DEDIOS, C
    MOHINO, F
    ORELLANA, G
    QUIROGA, ML
    ANALES DE QUIMICA, 1990, 86 (07): : 812 - 813
  • [6] Synthesis and antimicrobial evaluation of novel 1,3-thiazoles and unsymmetrical azines
    El-Kady, Mohamed
    Abbas, Eman M. H.
    Salem, Marwa S.
    Kassem, Asmaa F. M.
    Abd El-Moez, Sherein I.
    RESEARCH ON CHEMICAL INTERMEDIATES, 2016, 42 (04) : 3333 - 3349
  • [7] Synthesis of 2-Azido-1,3-thiazoles as 1,2,3-Triazole Precursors
    Pokhodylo, Nazariy T.
    Savka, Roman D.
    Pidlypnyi, Nazar I.
    Matiychuk, Vasyl S.
    Obushak, Mykola D.
    SYNTHETIC COMMUNICATIONS, 2010, 40 (03) : 391 - 399
  • [8] Synthesis and antimicrobial evaluation of novel 1,3-thiazoles and unsymmetrical azines
    Mohamed El-Kady
    Eman M. H. Abbas
    Marwa S. Salem
    Asmaa F. M. Kassem
    Sherein I. Abd El-Moez
    Research on Chemical Intermediates, 2016, 42 : 3333 - 3349
  • [9] A REGIOSELECTIVE SYNTHESIS OF 2,5-DI(METHYLSULFONYL)PHENOL
    ONO, M
    NAKAMURA, Y
    SATO, S
    ITOH, I
    CHEMISTRY LETTERS, 1988, (08) : 1393 - 1394
  • [10] NEW SYNTHESIS OF 2-OXOTETRAHYDRO-1,3-THIAZOLES (2-THIAZOLIDINONES)
    WOODGATE, PD
    LEE, HH
    RUTLEDGE, PS
    CAMBIE, RC
    SYNTHESIS-STUTTGART, 1977, (05): : 322 - 323
12345