The roles of ETS transcription factors in liver fibrosis

被引：0
|
作者：
Li-Ye Zhang
Yong Tan
Xiao-Jie Luo
Jiang-Feng Wu
Yi-Ran Ni
机构：
[1] China Three Gorges University,Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy
[2] China Three Gorges University,College of Basic Medical Science
[3] China Three Gorges University,Institute of Organ Fibrosis and Targeted Drug Delivery
来源：
Human Cell | 2023年 / 36卷
关键词：
ETS transcription factors; Liver fibrosis; ETS1; ETS2; PU.1; ERG; EHF; Small-molecule inhibitor;
D O I：
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中图分类号：
学科分类号：
摘要：
E26 transformation specific or E twenty-six (ETS) protein family consists of 28 transcription factors, five of which, named ETS1/2, PU.1, ERG and EHF, are known to involve in the development of liver fibrosis, and are expected to become diagnostic markers or therapeutic targets of liver fibrosis. In recent years, some small molecule inhibitors of ETS protein family have been discovered, which might open up a new path for the liver fibrosis therapy targeting ETS. This article reviews the research progress of ETS family members in the development liver fibrosis as well as their prospect of clinical application.
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页码：528 / 539
页数：11
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