The roles of ETS transcription factors in liver fibrosis

被引：0
|
作者：
Li-Ye Zhang
Yong Tan
Xiao-Jie Luo
Jiang-Feng Wu
Yi-Ran Ni
机构：
[1] China Three Gorges University,Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy
[2] China Three Gorges University,College of Basic Medical Science
[3] China Three Gorges University,Institute of Organ Fibrosis and Targeted Drug Delivery
来源：
Human Cell | 2023年 / 36卷
关键词：
ETS transcription factors; Liver fibrosis; ETS1; ETS2; PU.1; ERG; EHF; Small-molecule inhibitor;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
E26 transformation specific or E twenty-six (ETS) protein family consists of 28 transcription factors, five of which, named ETS1/2, PU.1, ERG and EHF, are known to involve in the development of liver fibrosis, and are expected to become diagnostic markers or therapeutic targets of liver fibrosis. In recent years, some small molecule inhibitors of ETS protein family have been discovered, which might open up a new path for the liver fibrosis therapy targeting ETS. This article reviews the research progress of ETS family members in the development liver fibrosis as well as their prospect of clinical application.
引用
收藏
页码：528 / 539
页数：11
相关论文
共 50 条
  • [1] The roles of ETS transcription factors in liver fibrosis
    Zhang, Li-Ye
    Tan, Yong
    Luo, Xiao-Jie
    Wu, Jiang-Feng
    Ni, Yi-Ran
    HUMAN CELL, 2023, 36 (02) : 528 - 539
  • [2] ETS transcription factors and their emerging roles in human cancer
    Seth, A
    Watson, DK
    EUROPEAN JOURNAL OF CANCER, 2005, 41 (16) : 2462 - 2478
  • [3] Ubiquitin-Mediated Control of ETS Transcription Factors: Roles in Cancer and Development
    Ducker, Charles
    Shaw, Peter E.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (10)
  • [4] THE ETS FAMILY OF TRANSCRIPTION FACTORS
    WASYLYK, B
    HAHN, SJL
    GIOVANE, A
    EUROPEAN JOURNAL OF BIOCHEMISTRY, 1993, 211 (1-2): : 7 - 18
  • [5] ETS transcription factors in endocrine systems
    Gutierrez-Hartmann, Arthur
    Duval, Dawn L.
    Bradford, Andrew P.
    TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2007, 18 (04): : 150 - 158
  • [6] Ets transcription factors and human disease
    Dittmer, J
    Nordheim, A
    BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 1998, 1377 (02): : F1 - F11
  • [7] Regulation of angiogenesis by ETS transcription factors
    Randi, Anna M.
    Sperone, Andrea
    Dryden, Nicola H.
    Birdsey, Graeme M.
    BIOCHEMICAL SOCIETY TRANSACTIONS, 2009, 37 : 1248 - 1253
  • [8] Prostate cancer and ETS transcription factors
    Wernert, Nicolas
    Shaikhibrahim, Zaki
    Kristiansen, Glen
    Perner, Sven
    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2011, 28 : S62 - S62
  • [9] Ets transcription factors and targets in osteogenesis
    Afshin Raouf
    Arun Seth
    Oncogene, 2000, 19 : 6455 - 6463
  • [10] ETS transcription factors and regulation of immunity
    Sarah Gallant
    Gary Gilkeson
    Archivum Immunologiae et Therapiae Experimentalis, 2006, 54 : 149 - 163
12345