Testing the Extent of Sequence Similarity Among Viroids, Satellite RNAs, and Hepatitis Delta Virus

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作者
Gareth M. Jenkins
Christopher H. Woelk
Andrew Rambaut
Edward C. Holmes
机构
[1] Wellcome Trust Centre for the Epidemiology of Infectious Disease,
[2] Department of Zoology,undefined
[3] University of Oxford,undefined
[4] South Parks Road,undefined
[5] Oxford OX1 3PS,undefined
[6] UK,undefined
[7] Department of Zoology,undefined
[8] University of Oxford,undefined
[9] South Parks Road,undefined
[10] Oxford OX1 3PS,undefined
[11] UK,undefined
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Key words: Viroids — Satellite RNAs — Hepatitis delta virus — Monte Carlo simulation — Sequence similarity;
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摘要
A Monte Carlo method was used to test the extent of sequence similarity among viroids, satellite RNAs, and hepatitis delta virus. This analysis revealed that there is insufficient sequence similarity among these pathogens to support the hypothesis that they have a common evolutionary origin. Furthermore, while definite patterns of sequence similarity were observed among some viroids, there was a clear lack of overall similarity, indicating that a monophyletic origin for even this group cannot be reliably supported from sequence data alone.
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页码:98 / 102
页数:4
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