The residue I257 at S4–S5 linker in KCNQ1 determines KCNQ1/KCNE1 channel sensitivity to 1-alkanols

被引:0
|
作者
Chang Xie
Hao-wen Liu
Na Pan
Jiu-ping Ding
Jing Yao
机构
[1] College of Life Sciences,
[2] Wuhan University,undefined
[3] Key Laboratory of Molecular Biophysics of the Ministry of Education,undefined
[4] College of Life Science and Technology,undefined
[5] Huazhong University of Science and Technology,undefined
来源
关键词
KCNQ1; KCNE1; current; ethanol; 1-butanol; 1-hexanol; closed-state channel block; open channel block;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:124 / 133
页数:9
相关论文
共 50 条
  • [21] Augmentation of KCNQ1/KCNE1 currents by insulin treatment
    Wu, Minghua
    Norota, Ikuo
    Ishii, Kuniaki
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011, 115 : 262P - 262P
  • [22] Rottlerin: Structure Modifications and KCNQ1/KCNE1 Ion Channel Activity
    Luebke, Marco
    Schreiber, Julian A.
    Le Quoc, Thang
    Koerber, Florian
    Mueller, Jasmin
    Sivanathan, Sivatharushan
    Matschke, Veronika
    Schubert, Janina
    Strutz-Seebohm, Nathalie
    Seebohm, Guiscard
    Scherkenbeck, Juergen
    CHEMMEDCHEM, 2020, 15 (12) : 1078 - 1088
  • [23] Insulin inhibits the KCNQ1/KCNE1 channel expressed in Xenopus oocytes
    Wu, Minghua
    Tsutakawa, Shusei
    Norota, Ikuo
    Ishii, Kuniaki
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010, 112 : 248P - 248P
  • [24] KCNE1 binds to the KCNQ1 pore to regulate potassium channel activity
    Melman, YF
    Um, SY
    Krumerman, A
    Kagan, A
    McDonald, TV
    NEURON, 2004, 42 (06) : 927 - 937
  • [25] Structure of KCNE1 and implications for how it modulates the KCNQ1 potassium channel
    Kang, Congbao
    Tian, Changlin
    Soennichsen, Frank D.
    Smith, Jarrod A.
    Meiler, Jens
    George, Alfred L., Jr.
    Vanoye, Carlos G.
    Kim, Hak Jun
    Sanders, Charles R.
    BIOCHEMISTRY, 2008, 47 (31) : 7999 - 8006
  • [26] Regulation of membrane KCNQ1/KCNE1 channel density by sphingomyelin synthase 1
    Wu, Meikui
    Takemoto, Makoto
    Taniguchi, Makoto
    Takumi, Toru
    Okazaki, Toshiro
    Song, Wen-Jie
    AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2016, 311 (01): : C15 - C23
  • [27] The IKs Channel Response to cAMP Is Modulated by the KCNE1:KCNQ1 Stoichiometry
    Thompson, Emely
    Eldstrom, Jodene
    Westhoff, Maartje
    McAfee, Donald
    Fedida, David
    BIOPHYSICAL JOURNAL, 2018, 115 (09) : 1731 - 1740
  • [28] Block of homomeric KCNQ1 and heteromeric KCNQ1/KCNE1 K+ channels by external barium.
    Ferrera, L
    Pusch, M
    BIOPHYSICAL JOURNAL, 2001, 80 (01) : 215A - 215A
  • [29] Block of homomeric KCNQ1 and heteromeric KCNQ1/KCNE1 K+ channels by intracellular Na+
    Pusch, M
    Ferrera, L
    Zimmermann, D
    Friedrich, T
    BIOPHYSICAL JOURNAL, 2001, 80 (01) : 216A - 216A
  • [30] KCNE1 Separates the Main Voltage Sensor Movement and Channel Opening in KCNQ1/KCNE1 Channels
    Barro-Soria, Rene
    Rebolledo, Santiago
    Liin, Sara I.
    Perez, Marta E.
    Sampson, Kevin
    Kass, Robert S.
    Larsson, H. Peter
    BIOPHYSICAL JOURNAL, 2014, 106 (02) : 142A - 142A