Partial gene suppression improves identification of cancer vulnerabilities when CRISPR-Cas9 knockout is pan-lethal

被引：0
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作者：
J. Michael Krill-Burger
Joshua M. Dempster
Ashir A. Borah
Brenton R. Paolella
David E. Root
Todd R. Golub
Jesse S. Boehm
William C. Hahn
James M. McFarland
Francisca Vazquez
Aviad Tsherniak
机构：
[1] Broad Institute of Harvard and MIT,
[2] Dana-Farber Cancer Institute,undefined
[3] Harvard Medical School,undefined
来源：
Genome Biology | / 24卷
关键词：
Functional genomics; Cancer genomics; Target identification; RNAi; CRISPR-Cas systems; CRISPR-Cas9 genome editing; Drug discovery;
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