Some Derivatives of 5α-Ketosteroid Hydrazones: Synthesis from Tigogenin and Antituberculosis Activity

被引：0
|
作者：
M. I. Merlani
E. P. Kemertelidze
K. Papadopoulos
N. I. Men'shova
机构：
[1] Academy of Sciences of Georgia,Kutateladze Institute of Pharmacochemistry
[2] National Research Center Demokritos,Institute of Physical Chemistry
[3] All-Russia Research Institute of Pharmaceutical Chemistry,Center for Drug Chemistry
来源：
Russian Journal of Bioorganic Chemistry | 2004年 / 30卷
关键词：
antimycobacterial activity; isonicotinoylhydrazones; 5α-ketosteroids; synthesis;
D O I：
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中图分类号：
学科分类号：
摘要：
Isonicotinoylhydrazones and thiosemicarbazones of some 5α-ketosteroids were synthesized from tigogenin, and their structures were confirmed by NMR and IR spectroscopy and mass spectrometry. Their antimycobacterial activities were studied and it was shown that some of the synthesized isonicotinoylhydrazones exhibit a high antituberculosis activity.
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页码：497 / 501
页数：4
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