IKKα takes control of canonical NF-κB activation

被引：0
|
作者：
Christiane Pelzer
Margot Thome
机构：
[1] University of Lausanne,Christiane Pelzer and Margot Thome are in the Department of Biochemistry
[2] Epalinges,undefined
[3] Switzerland.,undefined
来源：
Nature Immunology | 2011年 / 12卷
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摘要：
The kinase IKKα has a well-described activating role in the noncanonical transcription factor NF-κB pathway. Evidence now suggests that IKKα also inhibits the canonical NF-κB pathway by phosphorylating the scaffold protein TAX1BP1 to promote the assembly of the A20 ubiquitin-editing complex.
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页码：815 / 816
页数：1
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