Gene therapy of established mesothelioma xenografts with recombinant p16INK4a adenovirus

被引：0

作者：

Sandra P Frizelle

Jeffrey B Rubins

Joan X Zhou

David T Curiel

Robert A Kratzke

机构：

[1] Minneapolis Veterans Affairs Medical Center,The Department of Medicine and Research Service

[2] University of Minnesota Medical School,Department of Medicine

[3] Pulmonary and Critical Care Medicine,Department of Medicine

[4] University of Minnesota Medical School,undefined

[5] Gene Therapy Program,undefined

[6] University of Alabama,undefined

[7] Sections of Hematology/Oncology/Transplant,undefined

[8] University of Minnesota Medical School,undefined

来源：

Cancer Gene Therapy | 2000年 / 7卷

关键词：

p16; mesothelioma; tumor suppressor; gene therapy; cell cycle;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The absence of expression of the p16INK4a gene product is observed in virtually all mesothelioma tumors and cell lines, whereas wild-type pRB expression is maintained. We have examined the potential therapeutic role of re-expressing the p16INK4a gene product in mice with established human mesothelioma xenografts. Experiments using Adp16 treatments in mesothelioma xenografts demonstrated prolonged survival and potential cure following treatment with p16INK4a-based gene therapy. These results demonstrate that p16INK4a gene transfer may play a therapeutic role in the treatment of mesothelioma. Cancer Gene Therapy (2000) 7, 1421–1425

引用

页码：1421 / 1425

页数：4

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