Does intratympanic gadolinium injection predict efficacy of gentamicin partial chemolabyrinthectomy in Menière’s disease patients?

被引:0
|
作者
Gerd Claes
Luc Van den Hauwe
Floris Wuyts
Paul Van de Heyning
机构
[1] University of Antwerp,University Department of Otorhinolaryngology and Head and Neck Surgery, Antwerp University Hospital (UZA)
[2] University of Antwerp,AUREA (Antwerp University Research Centre for Equilibrium and Aerospace)
[3] University of Antwerp,University Department of Radiology, Antwerp University Hospital
来源
European Archives of Oto-Rhino-Laryngology | 2012年 / 269卷
关键词
Menière’s disease; Intratympanic; Gentamicin; Gadolinium; MRI;
D O I
暂无
中图分类号
学科分类号
摘要
Using actual diagnostic criteria, the diagnosis of certain Menière’s disease remains impossible during life without histopathologic confirmation. Assessing the value of a diagnostic test is difficult due to the lack of a gold standard. Recent studies reported on the use of MRI after intratympanic gadolinium injection to demonstrate endolymphatic hydrops in vivo. We evaluate whether MRI after intratympanic gadolinium administration is useful for predicting the effect and outcome of intratympanic gentamicin therapy. The correlation between transtympanic electrocochleographic (TT-ECoG) results and hydrops grade on MRI images is also investigated. Twelve definite Menière’s disease patients with incapacitating vertigo attacks, not responding to drug and behavioral treatment, were selected for partial chemolabyrinthectomy with intratympanic gentamicin. All patients underwent transtympanic electrocochleography followed by surgical middle ear inspection, partial chemolabyrinthectomy (gentamicin solution 40 mg/ml applied during 60 min) and intratympanic gadolinium injection with clear exposure of the round window membrane. The MR images were reviewed and a hydrops grade was assigned. Correlation between the hydrops grade and the electrocochleographic data was assessed. Only 5 of 12 patients showed gadolinium enhancement in the inner ear. However, 6 of the 7 patients that did not show postoperative intracochlear or intralabyrinthine gadolinium distribution did report the clinical improvement after intratympanic gentamicin therapy. Hydrops grade correlated with the result of transtympanic electrocochleography in four of five cases that showed gadolinium enhancement. We conclude that the use of intratympanic gadolinium has no added value in predicting the clinical outcome of intratympanic gentamicin application. However, based on these data, a correlation between the result of TT-ECoG and hydrops grading on MRI images can be suggested.
引用
收藏
页码:413 / 418
页数:5
相关论文
共 50 条
  • [41] Evaluation of the effect of intratympanic injection of gentamicin for resistant cases of Meniere’s disease on hearing and vestibular functions
    Baki F.
    Asal S.
    Shewel Y.
    Galal A.
    The Egyptian Journal of Otolaryngology, 2015, 31 (2) : 135 - 139
  • [42] Long-term hearing outcome in patients receiving intratympanic gentamicin for Meniere's disease
    Wu, IC
    Minor, LB
    LARYNGOSCOPE, 2003, 113 (05): : 815 - 820
  • [43] Clinical course of the patients with Meniere's disease and intratympanic injection therapy with dexamethasone
    Itoh, A
    Sakata, E
    EQUILIBRIUM RESEARCH, CLINICAL EQUILIBRIOMETRY AND MODERN TREATMENT, 2000, 1201 : 524 - 524
  • [44] Optimized 3D-FLAIR sequences to shorten the delay between intravenous administration of gadolinium and MRI acquisition in patients with Menière’s disease
    Juliette Barlet
    Alexis Vaussy
    Yohan Ejzenberg
    Michel Toupet
    Charlotte Hautefort
    André Gillibert
    Arnaud Attyé
    Michael Eliezer
    European Radiology, 2022, 32 : 6900 - 6909
  • [45] OCCLUSAL SPLINTS AS A THERAPEUTIC OPTION FOR PATIENTS WITH TEMPOROMANDIBULAR JOINT DISORDERS AND MENIÈRE'S DISEASE
    Tawk, Karen
    Vahidi, Ryka
    Khoshsar, Avissa
    Chao, Madeleine
    Abouzari, Mehdi
    Djalilian, Hamid R.
    OTOLOGY & NEUROTOLOGY, 2024, 45 (09) : 1091 - 1092
  • [46] Intratympanic gentamicin injection for refractory meniere's disease (MD) has potential effect in preventing contralateral MD occurrence
    Wu, Yongzhen
    Zhou, Yujuan
    Yu, Jing
    Song, Zijun
    Dai, Chunfu
    Wang, Jing
    ACTA OTO-LARYNGOLOGICA, 2021, 141 (07) : 657 - 662
  • [47] Long-term vertigo control in patients after intratympanic gentamicin instillation for Meniere's disease
    Bodmer, Daniel
    Morong, Sharon
    Stewart, Craig
    Alexander, Ashlin
    Chen, Joseph M.
    Nedzelski, Julian M.
    OTOLOGY & NEUROTOLOGY, 2007, 28 (08) : 1140 - 1144
  • [48] Long-term disability of class a patients with Meniere's disease after treatment with intratympanic gentamicin
    Soledad Boleas-Aguirre, Maria
    Sanchez-Ferrandiz, Noelia
    Guillen-Grima, Francisco
    Perez, Nicolas
    LARYNGOSCOPE, 2007, 117 (08): : 1474 - 1481
  • [49] MR Imaging of Meniere's Disease after Combined Intratympanic and Intravenous Injection of Gadolinium using HYDROPS2
    Naganawa, Shinji
    Yamazaki, Masahiro
    Kawai, Hisashi
    Bokura, Kiminori
    Iida, Tatsuo
    Sone, Michihiko
    Nakashima, Tsutomu
    MAGNETIC RESONANCE IN MEDICAL SCIENCES, 2014, 13 (02) : 133 - 137
  • [50] MRI performed after intratympanic gadolinium administration in patients with Meniere's disease: correlation with symptoms and signs
    Fiorino, Francesco
    Pizzini, Francesca B.
    Beltramello, Alberto
    Barbieri, Franco
    EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, 2011, 268 (02) : 181 - 187