Precision medicine for metastatic breast cancer—limitations and solutions

被引：0
|
作者：
Monica Arnedos
Cecile Vicier
Sherene Loi
Celine Lefebvre
Stefan Michiels
Herve Bonnefoi
Fabrice Andre
机构：
[1] Gustave Roussy and Université Paris Sud,Department of Medical Oncology
[2] INSERM Unit U981,Department of Biostatistics and Epidemiology
[3] Gustave Roussy and Université Paris Sud,Division of Research and Cancer Medicine
[4] Gustave Roussy and Université Paris Sud,Department of Medical Oncology and INSERM U916
[5] Peter MacCallum Cancer Centre,undefined
[6] University of Melbourne,undefined
[7] Institut Bergonié,undefined
来源：
Nature Reviews Clinical Oncology | 2015年 / 12卷
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摘要：
Recent research data defining the genomic landscape of breast cancer have reinforced the notion that this disease is driven by genomic alterationsSo far very few gene drivers validated in breast cancer have been identified, including ESR1, ERBB 2, PIK3CA and ATK1Identification of drivers, characterization of resistant clones, identification of DNA repair defects and mechanisms of immune suppression are potential uses of genomics to personalize medicineThe development of precision medicine for the treatment of breast cancer has several major challenges that include low frequency of targetable molecular alterations, feasibility of high-throughput technologies and availability of targeted therapy
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页码：693 / 704
页数：11
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