Assembly dynamics of microtubules at molecular resolution
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作者:
Jacob W. J. Kerssemakers
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机构:Foundation for Fundamental Research on Matter (FOM) Institute for Atomic and Molecular Physics (AMOLF),Department of Cell and Developmental Biology
Jacob W. J. Kerssemakers
E. Laura Munteanu
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机构:Foundation for Fundamental Research on Matter (FOM) Institute for Atomic and Molecular Physics (AMOLF),Department of Cell and Developmental Biology
E. Laura Munteanu
Liedewij Laan
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机构:Foundation for Fundamental Research on Matter (FOM) Institute for Atomic and Molecular Physics (AMOLF),Department of Cell and Developmental Biology
Liedewij Laan
Tim L. Noetzel
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机构:Foundation for Fundamental Research on Matter (FOM) Institute for Atomic and Molecular Physics (AMOLF),Department of Cell and Developmental Biology
Tim L. Noetzel
Marcel E. Janson
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机构:Foundation for Fundamental Research on Matter (FOM) Institute for Atomic and Molecular Physics (AMOLF),Department of Cell and Developmental Biology
Marcel E. Janson
Marileen Dogterom
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机构:Foundation for Fundamental Research on Matter (FOM) Institute for Atomic and Molecular Physics (AMOLF),Department of Cell and Developmental Biology
Marileen Dogterom
机构:
[1] Foundation for Fundamental Research on Matter (FOM) Institute for Atomic and Molecular Physics (AMOLF),Department of Cell and Developmental Biology
[2] Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) Dresden,undefined
A single-molecule approach was used to observe the growth dynamics of individual microtubules. Observations suggest that small tubulin oligomers can add directly to growing microtubules, and that the protein XMAP215 facilitates the addition of longer oligomers.