Antagonism of PPAR-γ signaling expands human hematopoietic stem and progenitor cells by enhancing glycolysis

被引：0
|
作者：
Bin Guo
Xinxin Huang
Man Ryul Lee
Sang A Lee
Hal E Broxmeyer
机构：
[1] Indiana University School of Medicine (IUSM),Department of Microbiology and Immunology
[2] Soonchunhyang Institute of Medi-bio Science (SIMS),undefined
[3] Soon Chun Hyang University,undefined
来源：
Nature Medicine | 2018年 / 24卷
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D O I：
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学科分类号：
摘要：
A small-molecule antagonist of PPAR-γ expands human cord blood HSPCs via downregulation of fructose 1,6-bisphosphatase expression, thereby enhancing glycolysis.
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页码：360 / 367
页数：7
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