The inhibitory receptor Tim-3 fails to suppress IFN-γ production via the NFAT pathway in NK-cell, unlike that in CD4+ T cells

被引:0
|
作者
Xiaowen Yu
Bin Lang
Xi Chen
Yao Tian
Shi Qian
Zining Zhang
Yajing Fu
Junjie Xu
Xiaoxu Han
Haibo Ding
Yongjun Jiang
机构
[1] The First Affiliated Hospital of China Medical University,NHC Key Laboratory of AIDS Immunology (China Medical University), National Clinical Research Center for Laboratory Medicine
[2] Key Laboratory of AIDS Immunology,Department of Clinical Laboratory
[3] Chinese Academy of Medical Sciences,Department of Clinical Laboratory
[4] The Affiliated Hospital of Qingdao University,undefined
[5] The Second Affiliated Hospital of Dalian Medical University,undefined
来源
关键词
Tim-3; IFN-γ; NK cells; NFAT; HIV infection;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [41] Autocrine NLPR3 inflammasome activity is critical to normal adaptive immunity via regulation of IFN-γ in CD4+ T cells
    West, Erin E.
    Arbore, Giuseppina
    Robertson, Avril A. B.
    Klos, Andreas
    Woodruff, Trent M.
    O'Neill, Luke A.
    Coll, Rebecca C.
    Sher, Alan
    Leonard, Warren J.
    Koehl, Joerg
    Monk, Pete
    Cooper, Matthew A.
    Afzali, Behdad
    Lachmann, Helen J.
    Cope, Andrew P.
    Mayer-Barber, Katrin
    Kemper, Claudia
    JOURNAL OF IMMUNOLOGY, 2016, 196
  • [42] An epithelial cell line that can stimulate alloproliferation of resting CD4+ T cells, but not after IFN-γ stimulation
    Lawson, C
    McCormack, AM
    Moyes, D
    Yun, S
    Fabre, JW
    Yacoub, M
    Rose, ML
    JOURNAL OF IMMUNOLOGY, 2000, 165 (02): : 734 - 742
  • [43] Interaction between Galectin-9/TIM-3 pathway and follicular helper CD4+ T cells contributes to viral persistence in chronic hepatitis C
    Zhuo, Ya
    Zhang, Yi-Fu
    Wu, Hong-Jie
    Qin, Lei
    Wang, Yan-Ping
    Liu, A-Min
    Wang, Xin-Hong
    BIOMEDICINE & PHARMACOTHERAPY, 2017, 94 : 386 - 393
  • [44] IL-4-mediated inhibition of IFN-γ production by CD4+ T cells proceeds by several developmentally regulated mechanisms
    Wurtz, O
    Bajénoff, M
    Guerder, S
    INTERNATIONAL IMMUNOLOGY, 2004, 16 (03) : 501 - 508
  • [45] IFN-β suppresses GM-CSF production by CD4+ T cells by inhibiting STAT5 signaling
    Rasouli, Javad
    Mari, Elisabeth Rose
    Ciric, Bogoljub
    Rostami, Abdolmohamad
    JOURNAL OF IMMUNOLOGY, 2016, 196
  • [46] Xingbi Gel Ameliorates Allergic Rhinitis by Regulating IFN-γ Gene Promoter Methylation in CD4+ T Cells via the ERK-DNMT Pathway
    Ai, Si
    Lin, Yueyong
    Zheng, Jian
    Zhuang, Xiangli
    FRONTIERS IN SURGERY, 2021, 7
  • [47] IFN-γ and STAT1 are required for efficient induction of CXC chemokine receptor 3 (CXCR3) on CD4+ but not CD8+ T cells
    Barbi, Joseph
    Oghumu, Steve
    Lezama-Davila, Claudio M.
    Satoskar, Abhay R.
    BLOOD, 2007, 110 (06) : 2215 - 2216
  • [48] B-cell co-receptor CD72 is expressed on NK cells and inhibits IFN-γ production but not cytotoxicity
    Alcon, Valeria L.
    Luther, Claudia
    Balce, Dale
    Takei, Fumio
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2009, 39 (03) : 826 - 832
  • [49] Myeloid-Derived Suppressor Cells Contribute to Susceptibility to Trypanosoma congolense Infection by Suppressing CD4+ T Cell Proliferation and IFN-γ Production
    Onyilagha, Chukwunonso
    Kuriakose, Shiby
    Ikeogu, Nnamdi
    Jia, Ping
    Uzonna, Jude
    JOURNAL OF IMMUNOLOGY, 2018, 201 (02): : 507 - 515
  • [50] IFN-α2b reduces IL-2 production and IL-2 receptor function in primary CD4+ T cells
    Zella, D
    Romerio, F
    Curreli, S
    Secchiero, P
    Cicala, C
    Zagury, D
    Gallo, RC
    JOURNAL OF IMMUNOLOGY, 2000, 164 (05): : 2296 - 2302