Cerebral cortical areas in which thickness correlates with severity of motor deficits of Parkinson’s disease

被引:0
|
作者
Chul Hyoung Lyoo
Young Hoon Ryu
Myung Sik Lee
机构
[1] Yonsei University College of Medicine,Department of Neurology, Gangnam Severance Hospital
[2] Yonsei University College of Medicine,Department of Nuclear Medicine, Gangnam Severance Hospital
[3] Yonsei University College of Medicine,Department of Neurology, Gangnam Severance Hospital, Brain Korea 21 Project for Medical Science
来源
Journal of Neurology | 2011年 / 258卷
关键词
Parkinson’s disease; Cortical thickness; Motor deficit;
D O I
暂无
中图分类号
学科分类号
摘要
The pathology of Parkinson’s disease (PD) is not confined to the nigrostriatal dopaminergic pathway, but also involves widespread cerebral cortical areas. Such non-nigrostriatal lesions may contribute to disabling dopa-resistant parkinsonian motor deficits. We performed cortical thickness analysis to identify cerebral cortical brain areas in which thickness correlates with the severity of parkinsonian motor deficits. We performed T1-weighted brain magnetic resonance imaging studies in 142 PD patients. Motor scores on the Unified Parkinson’s Disease Rating Scale (UPDRS) were measured, and subscores were calculated for bradykinesia, rigidity, tremor, and axial motor deficits. Using FreeSurfer software, we studied cortical areas in which thickness correlates with disease duration or the severity of parkinsonian motor deficits. The cortical thickness of the parieto-temporal association cortex, including the inferior parietal and posterior parietal cortices, showed a negative correlation with disease duration, total UPDRS motor score, and UPDRS subscores for bradykinesia and axial motor deficits. We found no cortical areas in which thickness correlated with subscores for tremor and rigidity. In addition to nigrostriatal dopaminergic deficit, progressive thinning of the parieto-temporal sensory association cortices related to disease duration seems to be related in part to the exacerbation of bradykinesia and the axial motor symptoms of PD.
引用
收藏
页码:1871 / 1876
页数:5
相关论文
共 50 条
  • [31] Motor Symptom Progression and Memory Deficits in Parkinson's Disease
    Chau, P. M.
    Lyons, K. E.
    Denney, D. R.
    Pahwa, R.
    Hanna-Pladdy, B.
    CLINICAL NEUROPSYCHOLOGIST, 2010, 24 (05) : 921 - 921
  • [32] Vocal motor deficits in a songbird model of Parkinson's disease
    Miller, J. E.
    Burkett, Z. D.
    Fox, C. M.
    White, S. A.
    MOVEMENT DISORDERS, 2011, 26 : S102 - S102
  • [33] Motor sequencing deficits in schizophrenia: A comparison with Parkinson's disease
    Sullivan, EV
    Fama, R
    Shear, PK
    Cahn-Weiner, DA
    Stein, M
    Zipursky, RB
    Pfefferbaum, A
    NEUROPSYCHOLOGY, 2001, 15 (03) : 342 - 350
  • [34] Neurocomputational models of motor and cognitive deficits in Parkinson's disease
    Wiecki, Thomas V.
    Frank, Michael J.
    RECENT ADVANCES IN PARKINSONS DISEASE: BASIC RESEARCH, 2010, 183 : 275 - 297
  • [35] Substantia nigra nigrosome-1 imaging correlates with the severity of motor symptoms in Parkinson's disease
    Chu, Yung-Tsai
    Yu, Chin-Feng
    Fan, Sung-Pin
    Chen, Ta-Fu
    Chiu, Ming-Jang
    Jang, Jyh-Shing Roger
    Chiu, Shu-, I
    Lin, Chin-Hsien
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2023, 451
  • [36] Glucocerebrosidase Activity is Reduced in Cryopreserved Parkinson's Disease Patient Monocytes and Inversely Correlates with Motor Severity
    Hughes, Laura P.
    Pereira, Marilia M. M.
    Hammond, Deborah A.
    Kwok, John B.
    Halliday, Glenda M.
    Lewis, Simon J. G.
    Dzamko, Nicolas
    JOURNAL OF PARKINSONS DISEASE, 2021, 11 (03) : 1157 - 1165
  • [37] Visuo-Motor Coordination Deficits and Motor Impairments in Parkinson's Disease
    Inzelberg, Rivka
    Schechtman, Edna
    Hocherman, Shraga
    PLOS ONE, 2008, 3 (11):
  • [38] A search for cortical correlates of trait impulsivity in Parkinson's disease
    Kubera, Katharina M.
    Schmitgen, Mike M.
    Nagel, Simon
    Hess, Klaus
    Herweh, Christian
    Hirjak, Dusan
    Sambataro, Fabio
    Wolf, Robert Christian
    BEHAVIOURAL BRAIN RESEARCH, 2019, 369
  • [39] Staging and clinical correlates of cortical thinning in Parkinson's disease
    Wilson, H.
    Niccolini, F.
    Pellicano, C.
    Piccini, P.
    Politis, M.
    MOVEMENT DISORDERS, 2016, 31 : S234 - S234
  • [40] Variations in cortical thickness with dementia severity in Alzheimer's disease
    Im, Kiho
    Lee, Jong-Min
    Seo, Sang Won
    Yoon, Uicheul
    Kim, Sung Tae
    Kim, Yun-Hee
    Kim, Sun I.
    Na, Duk L.
    NEUROSCIENCE LETTERS, 2008, 436 (02) : 227 - 231