Glial Reaction of the Subventricular Zone of the Telencephalon of the Rat Brain on Modeling of Alzheimer’s Disease

The aim of the present work was to study reactive changes in the subventricular zone (SVZ) of the lateral ventricles in the brain in rats at long time points after intraventricular administration of a neurotoxic substance, aggregated beta-amyloid peptide (BAP). At three months, ependymal cells in the SVZ responded to intraventricular administration of BAP by forming a characteristic gliotic structure similar to amyloid plaques in terms of composition, cell structures, and, probably, mechanism of formation. The atypical morphogenesis of these structures is suggested to result from the relationship between degenerative and regenerative processes involving both ependymal cells and progenitor cells of the proliferative zone of the telencephalon.