HIV-1 drug-resistance and drug-dependence

被引：0

作者：

Chris Baldwin

Ben Berkhout

机构：

[1] Academic Medical Center of the University of Amsterdam,Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam (CINIMA)

来源：

Retrovirology | / 4卷

关键词：

Enfuvirtide; Fusion Inhibitor; Conformational Switch; I37K Mutation; S138A Change;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

In this review, we will describe several recent HIV-1 studies in which a drug-dependent virus variant was selected. A common evolutionary route to the drug-dependence phenotype is proposed. First, the selection of a drug-resistance mutation that also affects the function of the targeted viral protein. Second, a compensatory mutation that repairs the protein function, but in the presence of the drug, which becomes an intrinsic part of the mechanism. The clinical relevance of drug-dependent HIV-1 variants is also discussed.

引用

共 50 条

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