Angiogenin mediates paternal inflammation-induced metabolic disorders in offspring through sperm tsRNAs

被引:0
|
作者
Yanwen Zhang
Li Ren
Xiaoxiao Sun
Zhilong Zhang
Jie Liu
Yining Xin
Jianmin Yu
Yimin Jia
Jinghao Sheng
Guo-fu Hu
Ruqian Zhao
Bin He
机构
[1] Nanjing Agricultural University,Key Laboratory of Animal Physiology & Biochemistry, Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine
[2] Zhejiang University School of Medicine,Institute of Environmental Medicine
[3] Nanjing Agricultural University,MOE Joint International Research Laboratory of Animal Health & Food Safety
[4] Tufts Medical Center,Division of Hematology and Oncology, Department of Medicine
来源
Nature Communications | / 12卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
Paternal environmental inputs can influence various phenotypes in offspring, presenting tremendous implications for basic biology and public health and policy. However, which signals function as a nexus to transmit paternal environmental inputs to offspring remains unclear. Here we show that offspring of fathers with inflammation exhibit metabolic disorders including glucose intolerance and obesity. Deletion of a mouse tRNA RNase, Angiogenin (Ang), abolished paternal inflammation-induced metabolic disorders in offspring. Additionally, Ang deletion prevented the inflammation-induced alteration of 5′-tRNA-derived small RNAs (5′-tsRNAs) expression profile in sperm, which might be essential in composing a sperm RNA ‘coding signature’ that is needed for paternal epigenetic memory. Microinjection of sperm 30–40 nt RNA fractions (predominantly 5′-tsRNAs) from inflammatory Ang+/+ males but not Ang–/– males resulted in metabolic disorders in the resultant offspring. Moreover, zygotic injection with synthetic 5′-tsRNAs which increased in inflammatory mouse sperm and decreased by Ang deletion partially resembled paternal inflammation-induced metabolic disorders in offspring. Together, our findings demonstrate that Ang-mediated biogenesis of 5′-tsRNAs in sperm contributes to paternal inflammation-induced metabolic disorders in offspring.
引用
收藏
相关论文
共 50 条
  • [31] Effects of paternal exposure to cigarette smoke on sperm DNA methylation and long-term metabolic syndrome in offspring
    Yunyun Liu
    Shengzhu Chen
    Dejian Pang
    Jiayi Zhou
    Xiuting Xu
    Si Yang
    Zhaofeng Huang
    Bolan Yu
    Epigenetics & Chromatin, 15
  • [32] Paternal Zn-deficiency abolishes metabolic effects in offspring induced by diet type
    Guanya Li
    Zhenglin Dong
    Shusheng Yue
    Dan Wan
    Yulong Yin
    Animal Nutrition, 2022, 8 (01) : 310 - 320
  • [33] Paternal Zn-deficiency abolishes metabolic effects in offspring induced by diet type
    Li, Guanya
    Dong, Zhenglin
    Yue, Shusheng
    Wan, Dan
    Yin, Yulong
    ANIMAL NUTRITION, 2022, 8 : 310 - 320
  • [34] Magnesium sulphate (Mg) prevents maternal inflammation-induced impairment of offspring learning ability and memory
    Ginsberg, Yuval
    Shickman, Vered
    Anunu, Ruchi
    Richter-Levin, Gal
    Weiner, Zeev
    Khatib, Nizar
    Ross, Michael
    Helek, Motti
    Beloosesky, Ron
    AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2014, 210 (01) : S122 - S122
  • [35] Magnesium sulfate prevents maternal inflammation-induced impairment of learning ability and memory in rat offspring
    Lamhot, Vered B.
    Khatib, Nizar
    Ginsberg, Yuval
    Anunu, Rachel
    Richter-Levin, Gal
    Weiner, Zeev
    Ross, Michael G.
    Divon, Michael Y.
    Hallak, Mordechai
    Beloosesky, Ron
    AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2015, 213 (06)
  • [36] NITRIC OXIDE MEDIATES INFLAMMATION-INDUCED APOPTOTIC FEATURES AND NEURONAL DYSFUNCTION AT AN EARLY STAGE OF NEURODEVELOPMENT
    Vaz, A. R.
    Silva, Leitao S.
    Barateiro, A.
    Falcao, A. S.
    Fernandes, A.
    Silva, R. F. M.
    Brito, M. A.
    Brites, D.
    GLIA, 2009, 57 (13) : S143 - S143
  • [37] LIVER DERIVED MIR-122 MEDIATES INFLAMMATION-INDUCED ANEMIA BY TARGETING ERYTHROPOIETIN IN THE KIDNEY
    Rivkin, M.
    Zorde-Khvalevsky, E.
    Simerzin, A.
    Chai, C.
    Yuval, J.
    Schneider, R.
    Heikenwalder, M.
    Galun, E.
    Giladi, H.
    JOURNAL OF HEPATOLOGY, 2016, 64 : S519 - S519
  • [38] TNFA mediates inflammation-induced effects on PPARG splicing in adipose tissue and mesenchymal precursor cells
    Cataldi, S.
    Aprile, M.
    Perfetto, C.
    Melillo, D.
    Giorgetti-Peraldi, S.
    Cormont, M.
    Italiani, P.
    Blueher, M.
    Tanti, J. -F.
    Ciccodicola, A.
    Costa, V.
    DIABETOLOGIA, 2021, 64 (SUPPL 1) : 27 - 27
  • [39] TNFα Mediates Inflammation-Induced Effects on PPARG Splicing in Adipose Tissue and Mesenchymal Precursor Cells
    Cataldi, Simona
    Aprile, Marianna
    Melillo, Daniela
    Mucel, Ines
    Giorgetti-Peraldi, Sophie
    Cormont, Mireille
    Italiani, Paola
    Blueher, Matthias
    Tanti, Jean-Francois
    Ciccodicola, Alfredo
    Costa, Valerio
    CELLS, 2022, 11 (01)
  • [40] Neuronal STING activation mediates inflammation-induced neurodegeneration via ferroptosis pathways in multiple sclerosis
    Weiyan Wang
    Mengdi Guo
    Xiao Tu
    Meiling Jiang
    CunJin Zhang
    Biophysics Reports, 2024, 10 (06) : 416 - 417