Increased exonic de novo mutation rate in individuals with schizophrenia

被引：0

作者：

Simon L Girard

Julie Gauthier

Anne Noreau

Lan Xiong

Sirui Zhou

Loubna Jouan

Alexandre Dionne-Laporte

Dan Spiegelman

Edouard Henrion

Ousmane Diallo

Pascale Thibodeau

Isabelle Bachand

Jessie Y J Bao

Amy Hin Yan Tong

Chi-Ho Lin

Bruno Millet

Nematollah Jaafari

Ridha Joober

Patrick A Dion

Si Lok

Marie-Odile Krebs

Guy A Rouleau

机构：

[1] Centre of Excellence in Neuromics of Université de Montréal,Department of Psychiatry

[2] Centre Hospitalier de l'Université de Montréal Research Center,Department of Pathology and Cellular Biology

[3] Centre of Excellence in Neuromics of Université de Montréal,Department of Medicine

[4] Centre Hospitalier Universitaire Sainte-Justine Research Center,undefined

[5] Genome Research Centre,undefined

[6] The Li Ka Shing Faculty of Medicine,undefined

[7] University of Hong Kong,undefined

[8] INSERM,undefined

[9] Université Paris Descartes,undefined

[10] Laboratoire de Physiopathologie des Maladies Psychiatriques,undefined

[11] Centre de Psychiatrie et Neurosciences (UMR 894),undefined

[12] Université Rennes 1,undefined

[13] CH Guillaume Régnier Service Hospitalo-Universitaire de Psychiatrie,undefined

[14] Université de Poitiers,undefined

[15] CHU,undefined

[16] Centre Hospitalier Henri Laborit,undefined

[17] Unité de recherche clinique intersectorielle en psychiatrie,undefined

[18] INSERM CIC-P 0802,undefined

[19] Douglas Mental Health University Institute,undefined

[20] McGill University,undefined

[21] Université de Montréal,undefined

[22] Université Paris Descartes,undefined

[23] Faculté de Médecine Paris Descartes,undefined

[24] Service Hospitalo Universitaire,undefined

[25] Centre Hospitalier Sainte-Anne,undefined

[26] Faculty of Medicine,undefined

[27] Université de Montréal,undefined

来源：

Nature Genetics | 2011年 / 43卷

关键词：

D O I：

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中图分类号：

学科分类号：

摘要：

Guy Rouleau, Marie-Odile Krebs and colleagues sequenced the exomes of 14 individuals with schizophrenia and their unaffected parents. Their findings support a role for de novo mutations in the etiology of schizophrenia and provide a list of genes that may contribute to disease pathogenesis.

引用

页码：860 / 863

页数：3

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