Genome sequence of the human malaria parasite Plasmodium falciparum

被引:0
|
作者
Malcolm J. Gardner
Neil Hall
Eula Fung
Owen White
Matthew Berriman
Richard W. Hyman
Jane M. Carlton
Arnab Pain
Karen E. Nelson
Sharen Bowman
Ian T. Paulsen
Keith James
Jonathan A. Eisen
Kim Rutherford
Steven L. Salzberg
Alister Craig
Sue Kyes
Man-Suen Chan
Vishvanath Nene
Shamira J. Shallom
Bernard Suh
Jeremy Peterson
Sam Angiuoli
Mihaela Pertea
Jonathan Allen
Jeremy Selengut
Daniel Haft
Michael W. Mather
Akhil B. Vaidya
David M. A. Martin
Alan H. Fairlamb
Martin J. Fraunholz
David S. Roos
Stuart A. Ralph
Geoffrey I. McFadden
Leda M. Cummings
G. Mani Subramanian
Chris Mungall
J. Craig Venter
Daniel J. Carucci
Stephen L. Hoffman
Chris Newbold
Ronald W. Davis
Claire M. Fraser
Bart Barrell
机构
[1] The Institute for Genomic Research,Department of Microbiology and Immunology
[2] The Wellcome Trust Sanger Institute,School of Life Sciences, The Wellcome Trust Biocentre
[3] The Wellcome Trust Genome Campus,Department of Biology and Genomics Institute
[4] Stanford Genome Technology Center,Plant Cell Biology Research Centre, School of Botany
[5] Liverpool School of Tropical Medicine,Department of Molecular and Cellular Biology, Berkeley Drosophila Genome Project
[6] Pembroke Place,undefined
[7] University of Oxford,undefined
[8] Weatherall Institute of Molecular Medicine,undefined
[9] John Radcliffe Hospital,undefined
[10] Drexel University College of Medicine,undefined
[11] The University of Dundee,undefined
[12] University of Pennsylvania,undefined
[13] University of Melbourne,undefined
[14] Celera Genomics,undefined
[15] University of California,undefined
[16] The Center for the Advancement of Genomics,undefined
[17] Malaria Program,undefined
[18] Naval Medical Research Center,undefined
[19] Syngenta,undefined
[20] Jealott's Hill International Research Centre,undefined
[21] Sanaria,undefined
来源
Nature | 2002年 / 419卷
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摘要
The parasite Plasmodium falciparum is responsible for hundreds of millions of cases of malaria, and kills more than one million African children annually. Here we report an analysis of the genome sequence of P. falciparum clone 3D7. The 23-megabase nuclear genome consists of 14 chromosomes, encodes about 5,300 genes, and is the most (A + T)-rich genome sequenced to date. Genes involved in antigenic variation are concentrated in the subtelomeric regions of the chromosomes. Compared to the genomes of free-living eukaryotic microbes, the genome of this intracellular parasite encodes fewer enzymes and transporters, but a large proportion of genes are devoted to immune evasion and host–parasite interactions. Many nuclear-encoded proteins are targeted to the apicoplast, an organelle involved in fatty-acid and isoprenoid metabolism. The genome sequence provides the foundation for future studies of this organism, and is being exploited in the search for new drugs and vaccines to fight malaria.
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页码:498 / 511
页数:13
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