Integration of genomics, proteomics, and imaging for cardiac stem cell therapy

Cardiac stem cell therapy is beginning to mature as a valid treatment for heart disease. As more clinical trials utilizing stem cells emerge, it is imperative to establish the mechanisms by which stem cells confer benefit in cardiac diseases. In this paper, we review three methods—molecular cellular imaging, gene expression profiling, and proteomic analysis—that can be integrated to provide further insights into the role of this emerging therapy.