Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function

被引：0
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作者：
Cong Zhang
Ana Maria Cuervo
机构：
[1] Marion Bessin Liver Research Center and Institute for Aging Research,Department of Developmental and Molecular Biology and Department of Anatomy and Structural Biology
来源：
Nature Medicine | 2008年 / 14卷
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摘要：
Chaperone-mediated autophagy (CMA), a mechanism for the lysosomal degradation of proteins, declines in aging cells. Using transgenic mice in which such a decline does not occur in the liver, the authors found that preserving CMA leads to reduced accumulation of damaged proteins and improved organ function in aged mice (pages 909–910).
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页码：959 / 965
页数：6
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