Cerebral edema associated with meningiomas: the role of peritumoral brain tissue

被引:0
|
作者
Rui Vaz
Nuno Borges
Celso Cruz
Isabel Azevedo
机构
[1] Department of Neurology and Neurosurgery,
[2] Medical Faculty,undefined
[3] Hospital S. João,undefined
[4] Institute of Pharmacology and Therapeutics,undefined
[5] Medical Faculty,undefined
[6] Hospital S. João,undefined
来源
Journal of Neuro-Oncology | 1998年 / 36卷
关键词
blood-brain barrier; brain edema; meningiomas; peritumoral vessels;
D O I
暂无
中图分类号
学科分类号
摘要
We undertook a morphological study of small pieces of peritumoral brain tissue removed from seven patients with meningiomas submitted to surgery. All patients had cerebral edema, as shown by preoperative C.T. and N.M.R.. Control specimens were obtained from five patients undergoing ventriculo-peritoneal shunt. The tissue fragments were fixed in glutaraldehyde-osmium and embedded in Epon. In semi-thin sections observed under light microscopy peritumoral endothelial cells exhibited voluminous cytoplasm and nucleus. Morphometrical evaluation confirmed that these endothelial cell nuclei were significantly larger than controls. Under the electron microscope those cells showed nuclei rich in euchromatin and cytoplasm rich in pinocytotic vesicles. The morphological changes observed suggest a process of dedifferentiation of brain peritumoral capillary cells and are compatible with an increase in permeability. Both events, which may be due to diffusion of a tumoral vascular permeability factor, favour the hypothesis that peritumoral brain tissue contributes to edema fluid that accumulates around meningiomas.
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页码:285 / 291
页数:6
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