Determination of zolpidem and its metabolites by chromatography-mass spectrometry

被引：0
|
作者：
E. A. Krylova
S. S. Kataev
Yu. A. Khomov
机构：
[1] Perm Regional Bureau of Forensic Medical Examination,
[2] Perm State Pharmaceutical Academy,undefined
来源：
Journal of Analytical Chemistry | 2013年 / 68卷
关键词：
zolpidem; metabolism; solid-phase extraction; gas chromatography; mass spectrometric detection;
D O I：
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中图分类号：
学科分类号：
摘要：
Conditions of the simultaneous isolation of various types of zolpidem metabolites from samples of real urine by solid-phase extraction have been optimized. Various derivatives of zolpidem hydroxy- and carboxy-metabolites were obtained; their mass-spectral and gas-chromatographic characteristics have been studied. The results ensure the reliable identification of zolpidem metabolites by gas chromatography-mass spectrometry for chemical toxicological and forensic investigations.
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页码：722 / 729
页数：7
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