Application of liquid chromatography-mass spectrometry in the determination of oxazaphosphorines and their metabolites

被引：4
|
作者：
Baumann, F [1 ]
Preiss, R [1 ]
机构：
[1] Univ Leipzig, Inst Clin Pharmacol, D-04107 Leipzig, Germany
来源：
ANALYTICA CHIMICA ACTA | 2003年 / 492卷 / 1-2期
关键词：
oxazaphosphorine; metabolite; LC-MS; LC-MS-MS; GC-MS;
D O I：
10.1016/S0003-2670(03)00892-4
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
This article presents an overview of the methods of bioanalysis of oxazaphosphorines and their metabolites, in particular liquid chromatography-mass spectrometry (LC-MS) and liquid chromatography-tandem mass spectrometry (LC-MS-NlS) assays. Especially for the molecules that do not contain chromophores as oxazaphosphorines the mass spectrometry took an important place in chromatographic analysis. For trace analysis the LC-MS-MS methods are particularly well suited. Above all gas chromatography-mass spectrometry (GC-MS) assays were applied for the determination of these substances, in addition, LC-MS methods and other high-performance liquid chromatography (HPLC) or GC methods were included in the consideration. (C) 2003 Elsevier B.V. All rights reserved.
引用
收藏
页码：147 / 156
页数：10
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