Fractional Tumour-Immune Model with Drug Resistance

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作者
Ana P. S. Koltun
José Trobia
Antonio M. Batista
Ervin K. Lenzi
Moises S. Santos
Fernando S. Borges
Kelly C. Iarosz
Iberê L. Caldas
Enrique C. Gabrick
机构
[1] State University of Ponta Grossa,Graduate Program in Science
[2] State University of Ponta Grossa,Department of Mathematics and Statistics
[3] State University of Ponta Grossa,Department of Physics
[4] Municipal Secretary of Education of Ponta Grossa,Department of Physiology and Pharmacology
[5] State University of New York Downstate Health Sciences University,Center for Mathematics, Computation, and Cognition
[6] Federal University of ABC,Physics Intitute
[7] University Center UNIFATEB,undefined
[8] University of São Paulo,undefined
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Tumour; Cancer model; Fractional calculus;
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摘要
Cancer is a group of diseases in which cells grow uncontrollably and can spread into other tissues. Various studies consider the interactions between cancer cells and the immune system as well as different types of treatment. Mathematical models have been used to study the growth of cancerous cells. We study a fractional order model that describes some aspects of the interactions among host, effector immune, and cancer cells. A drug treatment is considered to analyse the cancerous cells proliferation. Due to the chemotherapy, we split the fractional equation of the cancerous cells into drug sensitivity and resistance. We show that not only the chemotherapy but also the drug resistance plays an important role in the growth rate of cancer cells.
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