Phase I dose-escalation study of AZD7762, a checkpoint kinase inhibitor, in combination with gemcitabine in US patients with advanced solid tumors

被引:0
|
作者
Edward Sausville
Patricia LoRusso
Michael Carducci
Judith Carter
Mary F. Quinn
Lisa Malburg
Nilofer Azad
David Cosgrove
Richard Knight
Peter Barker
Sonya Zabludoff
Felix Agbo
Patricia Oakes
Adrian Senderowicz
机构
[1] University of Maryland,Marlene and Stewart Greenebaum Cancer Center
[2] Wayne State University School of Medicine,Karmanos Cancer Center
[3] Johns Hopkins Medical Institutions,Sidney Kimmel Comprehensive Cancer Center
[4] AstraZeneca,undefined
来源
关键词
AZD7762; Chk1; Solid tumors; Phase I; Safety; Pharmacokinetics;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:539 / 549
页数:10
相关论文
共 50 条
  • [41] Phase I dose-escalation study of plitidepsin in combination with bevacizumab in patients with refractory solid tumors
    Aspeslagh, Sandrine
    Awada, Ahmad
    Matos-Pita, Arturo S.
    Aftimos, Philippe
    Bahleda, Ratislav
    Varga, Andrea
    Soria, Jean-Charles
    ANTI-CANCER DRUGS, 2016, 27 (10) : 1021 - 1027
  • [42] Phase I/Ib dose-escalation study of aveluma in Chinese patients with advanced solid tumors
    Wu, Yi-Long
    Cheng, Ying
    Chen, Huajun
    Tu, Haiyan
    Xu, Chongrui
    Wang, Zhen
    Liu, Ying
    Xin, Ying
    Lou, Haizhou
    Wang, Wei
    Chin, Kevin
    Li, Dandan
    Zhao, Di
    Gao, Yanfei
    Xu, Wenping
    Pan, Hongming
    FUTURE ONCOLOGY, 2022,
  • [43] A phase I dose-escalation and pharmacokinetic study of enzastaurin and erlotinib in patients with advanced solid tumors
    Padda, Sukhmani K.
    Krupitskaya, Yelena
    Chhatwani, Laveena
    Fisher, George A.
    Colevas, Alexander D.
    Pedro-Salcedo, Melanie San
    Decker, Rodney
    Latz, Jane E.
    Wakelee, Heather A.
    CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2012, 69 (04) : 1013 - 1020
  • [44] A PHASE I DOSE-ESCALATION STUDY OF EMD 1214063, AN ORAL SELECTIVE CMET INHIBITOR, IN PATIENTS WITH ADVANCED SOLID TUMORS
    Naing, A.
    Falchook, G. S.
    Fu, S.
    Amin, H. M.
    Piha-Paul, S. A.
    Hong, D. S.
    Tsimberidou, A. M.
    Wheler, J. J.
    Janku, F.
    Klevesath, M. B.
    Jego, V.
    Johne, A.
    Kurzrock, R.
    ANNALS OF ONCOLOGY, 2012, 23 : 21 - 21
  • [45] Tesetaxel, a new oral taxane, in combination with capecitabine: a phase I, dose-escalation study in patients with advanced solid tumors
    Saif, Muhammad Wasif
    Sarantopoulos, John
    Patnaik, Amita
    Tolcher, Anthony W.
    Takimoto, Chris
    Beeram, Murali
    CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2011, 68 (06) : 1565 - 1573
  • [46] A Phase I dose-escalation study of afatinib combined with nintedanib in patients with advanced solid tumors
    Gordon, Michael S.
    Springett, Gregory M.
    Su, Yungpo Bernard
    Ould-Kaci, Mahmoud
    Wind, Sven
    Zhao, Yihua
    LoRusso, Patricia M.
    FUTURE ONCOLOGY, 2015, 11 (10) : 1479 - 1491
  • [47] A Phase I Dose-Escalation and Expansion Study of Telaglenastat in Patients with Advanced or Metastatic Solid Tumors
    Harding, James J.
    Telli, Melinda
    Munster, Pamela
    Voss, Martin H.
    Infante, Jeffrey R.
    DeMichele, Angela
    Dunphy, Mark
    Le, Mai H.
    Molineaux, Chris
    Orford, Keith
    Parlati, Frank
    Whiting, Sam H.
    Bennett, Mark K.
    Tannir, Nizar M.
    Meric-Bernstam, Funda
    CLINICAL CANCER RESEARCH, 2021, 27 (18) : 4994 - 5003
  • [48] Phase I dose-escalation study of brostallicin, a minor groove binder, in combination with cisplatin in patients with advanced solid tumors
    F. Caponigro
    D. Lorusso
    G. Fornari
    C. Barone
    M. Merlano
    M. Airoldi
    M. Schena
    R. MacArthur
    S. Weitman
    M. G. Jannuzzo
    S. Crippa
    F. Fiorentini
    A. Petroccione
    S. Comis
    Cancer Chemotherapy and Pharmacology, 2010, 66 : 389 - 394
  • [49] Phase I dose-escalation study of brostallicin, a minor groove binder, in combination with cisplatin in patients with advanced solid tumors
    Caponigro, F.
    Lorusso, D.
    Fornari, G.
    Barone, C.
    Merlano, M.
    Airoldi, M.
    Schena, M.
    MacArthur, R.
    Weitman, S.
    Jannuzzo, M. G.
    Crippa, S.
    Fiorentini, F.
    Petroccione, A.
    Comis, S.
    CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2010, 66 (02) : 389 - 394
  • [50] A phase I dose-escalation and pharmacokinetic study of enzastaurin and erlotinib in patients with advanced solid tumors
    Sukhmani K. Padda
    Yelena Krupitskaya
    Laveena Chhatwani
    George A. Fisher
    Alexander D. Colevas
    Melanie San Pedro-Salcedo
    Rodney Decker
    Jane E. Latz
    Heather A. Wakelee
    Cancer Chemotherapy and Pharmacology, 2012, 69 : 1013 - 1020