Antioxidative and myocardial protective effects of L-arginine in oxygen radical-induced injury of isolated perfused rat hearts

被引：0
|
作者：
Astrid Suessenbacher
Achim Lass
Bernd Mayer
Friedrich Brunner
机构：
[1] Institut für Pharmakologie und Toxikologie,
[2] Karl-Franzens-Universität Graz,undefined
[3] Universitätsplatz 2,undefined
[4] 8010 Graz,undefined
[5] Austria,undefined
来源：
Naunyn-Schmiedeberg's Archives of Pharmacology | 2002年 / 365卷
关键词：
Free radical scavenging L-arginine Superoxide dismutase Rat heart Contractile function Coronary circulation Cardioprotection Chemiluminescence;
D O I：
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学科分类号：
摘要：
Oxygen-derived free radicals and oxidants (reactive oxygen intermediates, ROI) have been implicated in cardiovascular diseases. The protective role of nitric oxide (NO) against ROI-mediated tissue injury is not resolved. We tested the effects of exogenous NO, L- and D-arginine and a NO synthase inhibitor on electrolysis-induced cardiac injury and the generation of ROI by electrolysis. Superoxide dismutase (SOD) and catalase were used for comparison.
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页码：269 / 276
页数：7
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