Interactions between riluzole and conventional antiepileptic drugs – a comparison of results obtained in the subthreshold method and isobolographic analysis

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作者
K. K. Borowicz
M. Świąder
E. Drelewska
S. J. Czuczwar
机构
[1] Medical University,Department of Pathophysiology
[2] Medical University,Department of Pharmacology
[3] Isotope Laboratory,undefined
[4] Institute of Agricultural Medicine,undefined
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Keywords: Riluzole, antiepileptic drugs, electroshock maximal, isobolographic analysis;
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摘要
The exact types of pharmacodynamic interactions between riluzole and conventional antiepileptic drugs were evaluated in two available ways, the subthreshold and isobolographic analysis. Maximal electroshock test in mice was used as an animal model for generalized tonic-clonic convulsions.
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页码:1511 / 1522
页数:11
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