Building a new conceptual framework for receptor heteromers

被引：0

作者：

Sergi Ferré

Ruben Baler

Michel Bouvier

Marc G Caron

Lakshmi A Devi

Thierry Durroux

Kjell Fuxe

Susan R George

Jonathan A Javitch

Martin J Lohse

Ken Mackie

Graeme Milligan

Kevin D G Pfleger

Jean-Philippe Pin

Nora D Volkow

Maria Waldhoer

Amina S Woods

Rafael Franco

机构：

[1] Sergi Ferré is at the National Institute on Drug Abuse,Marc G. Caron is in the Department of Cell Biology

[2] IRP,undefined

[3] NIH,undefined

[4] DHHS,undefined

[5] 251 Bayview Boulevard,undefined

[6] Baltimore,undefined

[7] Maryland 21224,undefined

[8] USA.,undefined

[9] Ruben Baler is at the National Institute on Drug Abuse,undefined

[10] NIH,undefined

[11] DHHS,undefined

[12] 6001 Executive Boulevard,undefined

[13] Bethesda,undefined

[14] Maryland 20892,undefined

[15] USA.,undefined

[16] Michel Bouvier is at the Institute for Research in Immunology and Cancer,undefined

[17] Université de Montreal,undefined

[18] C.P. 6128 Succursale Centre-Ville,undefined

[19] Montreal,undefined

[20] Quebec H3C 3J7,undefined

[21] Canada.,undefined

[22] Duke University Medical Center,undefined

[23] Durham,undefined

[24] North Carolina 27710,undefined

[25] USA.,undefined

[26] Lakshmi A. Devi is at the Mount Sinai School of Medicine,undefined

[27] 1468 Madison Avenue,undefined

[28] New York,undefined

[29] New York 10029,undefined

[30] USA.,undefined

[31] Thierry Durroux is at the Institut de Génomique Fonctionelle,undefined

[32] CNRS,undefined

[33] INSERM,undefined

[34] University of Montpellier,undefined

[35] 141 Rue de la Cardonille,undefined

[36] Montpellier F-34000,undefined

[37] France.,undefined

[38] Kjell Fuxe is at the Karolinska Institute,undefined

[39] Retziusvag 8,undefined

[40] Stockholm 17177,undefined

[41] Sweden.,undefined

[42] Susan R. George is at the Center for Addiction and Mental Health,undefined

[43] University of Toronto,undefined

[44] 1 King's College Circle,undefined

[45] Toronto,undefined

[46] Ontario M5S 1A8,undefined

[47] Canada.,undefined

[48] Jonathan A. Javitch is at the Center for Molecular Recognition,undefined

[49] Columbia University,undefined

[50] College of Physicians and Surgeons,undefined

来源：

Nature Chemical Biology | 2009年 / 5卷

关键词：

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中图分类号：

学科分类号：

摘要：

Receptor heteromers constitute a new area of research that is reshaping our thinking about biochemistry, cell biology, pharmacology and drug discovery. In this commentary, we recommend clear definitions that should facilitate both information exchange and research on this growing class of transmembrane signal transduction units and their complex properties. We also consider research questions underlying the proposed nomenclature, with recommendations for receptor heteromer identification in native tissues and their use as targets for drug development.

引用

页码：131 / 134

页数：3

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