Effect of Renal Impairment on the Pharmacokinetics of Pradigastat, a Novel Diacylglycerol Acyltransferase1 (DGAT1) Inhibitor

被引：0
|
作者：
Sachiko Mita
Dan Meyers
Parasar Pal
TsuHan Lin
Tapan Majumdar
Sam Rebello
Gangadhar Sunkara
Jin Chen
机构：
[1] Novartis Pharma K.K.,
[2] Novartis Institutes for BioMedical Research,undefined
[3] Novartis Healthcare Private Limited,undefined
[4] Alcon Laboratories,undefined
[5] Inc.,undefined
[6] Novartis Institutes for BioMedical Research,undefined
来源：
Clinical Pharmacokinetics | 2015年 / 54卷
关键词：
Pharmacokinetic Parameter; Renal Impairment; Severe Renal Impairment; Moderate Renal Impairment; Matched Healthy Control;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：751 / 760
页数：9
相关论文
共 50 条
  • [31] Type I diacylglycerol acyltransferase (DGAT1) from the unicellular green alga Haematococcus pluvialis is a xanthophyll acyltransferase
    Ma, Haiyan
    Cao, Li
    Wei, Ziwang
    Zheng, Jie
    Zou, Song
    Zhao, Liang
    Li, Yanhua
    Hu, Qiang
    Han, Danxiang
    ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS, 2022, 64
  • [32] Cloning and Molecular Characterization of the Acyl-CoA:Diacylglycerol Acyltransferase 1 (DGAT1) Gene from Echium
    Manas-Fernandez, A.
    Vilches-Ferron, M.
    Garrido-Cardenas, J. A.
    Belarbi, E. -H.
    Alonso, D. L.
    Garcia-Maroto, F.
    LIPIDS, 2009, 44 (06) : 555 - 568
  • [33] DIACYLGLYCEROL ACYLTRANSFERASE 1 (DGAT1) FUNCTIONS AS A CELLULAR "HUB" FOR HCV NS5A AND CORE PROTEINS
    Modi, Ankit A.
    Camus, Gregory
    Herker, Eva
    Ott, Melanie
    HEPATOLOGY, 2011, 54 : 1336A - 1336A
  • [34] A Practical Synthesis of a Potent and Selective Diacylglycerol Acyltransferase-1 (DGAT-1) Inhibitor
    Shin, Youngsook
    Bergeron, Philippe
    Fox, Brian M.
    Kayser, Frank
    McGee, Lawrence R.
    McKendry, Sharon
    McMinn, Dustin L.
    Labelle, Marc
    Cushing, Timothy D.
    SYNTHESIS-STUTTGART, 2014, 46 (22): : 3047 - 3058
  • [35] Variations in the diacylglycerol acyltransferase-1 (DGAT1) and its association with meat tenderness in Gannan yaks (Bos grunniens)
    Gao, Xiaoli
    Shi, Bingang
    Shi, Xuehong
    Zuo, Zhi
    Zhao, Zhidong
    Wang, Jiqing
    Liu, Xiu
    Luo, Yuzhu
    Hu, Jiang
    ITALIAN JOURNAL OF ANIMAL SCIENCE, 2020, 19 (01) : 1026 - 1034
  • [36] Targeting Acyl-CoA:Diacylglycerol Acyltransferase 1 (DGAT1) with Small Molecule Inhibitors for the Treatment of Metabolic Diseases
    Cao, Jingsong
    Zhou, Yingjiang
    Peng, Haibing
    Huang, Xinyi
    Stahler, Shannon
    Suri, Vipin
    Qadri, Ariful
    Gareski, Tiffany
    Jones, Juli
    Hahm, Seung
    Perreault, Mylene
    McKew, John
    Shi, Mengxiao
    Xu, Xin
    Tobin, James F.
    Gimeno, Ruth E.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (48) : 41838 - 41851
  • [37] Specific Role for Acyl CoA:Diacylglycerol Acyltransferase 1 (Dgat1) in Hepatic Steatosis Due to Exogenous Fatty Acids
    Villanueva, Claudio J.
    Monetti, Mara
    Shih, Michelle
    Zhou, Ping
    Watkins, Steve M.
    Bhanot, Sanjay
    Farese, Robert V., Jr.
    HEPATOLOGY, 2009, 50 (02) : 434 - 442
  • [38] Frequency and effect of the bovine acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) K232A polymorphism in Swedish dairy cattle
    Naslund, J.
    Fikse, W. F.
    Pielberg, G. R.
    Lunden, A.
    JOURNAL OF DAIRY SCIENCE, 2008, 91 (05) : 2127 - 2134
  • [39] Identification and characterization of an efficient acyl-CoA: diacylglycerol acyltransferase 1 (DGAT1) gene from the microalga Chlorella ellipsoidea
    Xuejie Guo
    Chengming Fan
    Yuhong Chen
    Jingqiao Wang
    Weibo Yin
    Richard R. C. Wang
    Zanmin Hu
    BMC Plant Biology, 17
  • [40] Exploring novel single nucleotide polymorphisms and haplotypes of the diacylglycerol O-acyltransferase 1 (DGAT1) gene and their effects on protein structure in Iranian buffalo
    Masoumeh Naserkheil
    Seyed Reza Miraie-Ashtiani
    Mostafa Sadeghi
    Ardeshir Nejati-Javaremi
    Chae-Won Park
    Kwan-Sik Min
    Deukhwan Lee
    Genes & Genomics, 2019, 41 : 1265 - 1271
12345