The synthesis and investigation of the antimicrobial activity of some new phenylselanyl-1-(toluene-4-sulfonyl)-1H-tetrazole derivatives

被引：0

作者：

Yılmaz Yıldırır

M. Faruk Us

Naki Çolak

Hamdi Özkan

Serkan Yavuz

Ali Disli

Sahlan Ozturk

Lemi Turker

机构：

[1] Gazi University,Faculty of Science and Arts, Chemistry Department

[2] Central Veterinary Controls and Research Institute,Faculty of Science and Arts, Biology Department

[3] Gazi University,Faculty of Science and Arts, Chemistry Department

[4] Middle East Technical University,undefined

来源：

Medicinal Chemistry Research | 2009年 / 18卷

关键词：

Tetrazole toluenesulfonic acid; Antimicrobial activity; SMX; SRZ;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The sulfonamide functional group has aroused interest in both medicinal and bioorganic chemistry. In this study, some new phenylselanyl–1–(toluene-4-sulfonyl)-1H-tetrazole derivatives (2a–f) have been synthesized using dicyclohexylcarbodiimide/dimethylaminopyridine (DCC/DMAP). The structures of the presently synthesized compounds were elucidated by spectroscopic methods [Fourier-transform infrared (FTIR) spectroscopy, 1H nuclear magnetic resonance (NMR), 13C nuclear magnetic resonance-attached proton test (13C NMR-APT), and mass spectrometry (MS)]. In addition, the antimicrobial activity of the synthesized compounds and two antibiotics [sulfamethoxazole (SMX) and sulfamerazine (SRZ)] were investigated against some microorganisms.

引用

页码：91 / 97

页数：6

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