193 The Rna-Binding Protein Rbm3 is Involved in Hypothermia Induced Neuroprotection

被引：0
|
作者：
S Wellmann
A Zelmer
C Nitsch
H U Bucher
C Bührer
机构：
[1] University Hospital Zürich,Department of Neonatology
[2] University Children's Hospital Basel,Department of Neonatology
[3] University Basel,Department of Neuroanatomy
[4] Charité University Medical Center,Department of Neonatology
来源：
Pediatric Research | 2010年 / 68卷
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摘要：
Background: Induced hypothermia is the only therapy with proven efficacy to reduce brain damage after perinatal asphyxia. While hypothermia downregulates global protein synthesis and cell metabolism, low temperature induces a small subset of proteins that includes the RNA-binding protein RBM3, which is transcriptionally induced also in response to hypoxia and has recently been implicated in cell survival.
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页码：101 / 101
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